Biradical polarizing agents for dynamic nuclear polarization

Details Biradical polarizing agents for dynamic nuclear polarization Biradical polarizing agents for dynamic nuclear polarization

2011-07-26

2011-07-26

Soderquist, Arlen (Department: 1777)

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

C514S332000, C546S116000, C546S188000, C546S193000, C548S519000, C548S542000

Reexamination Certificate

active

07985594

ABSTRACT:
The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q1and Q2are different when X1and X2are —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.

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