Bipyridinyl derivatives as a highly selective...

Details Bipyridinyl derivatives as a highly selective... Bipyridinyl derivatives as a highly selective...

2005-09-20

2005-09-20

Davis, Zinna Northington (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06946558

ABSTRACT:
The present invention relates to a novel bipyridinyl derivative having a structure of formula (1) and its pharmaceutically acceptable salts, optical isomer and method for preparing it as a highly selective cyclooxygenase-2 inhibitor, wherein R is defined in this specification.

REFERENCES:
Vane (Jan. 1994) Nature 367:215-216.
Battistini et al. (Oct. 1994) Drug News and Perspectives, 7:501-512.
Reitz and Seibert (1995) Annual Reports in Medicinal Chemistry 30:179-188.
Leblanc et al. (1995) Bioorganic & Medicinal Chemistry Letters 5(18):2123-2128.
Penning et al. (1997) Journal of Medicinal Chemistry 40:1347-1365.

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