Bipyrazole derivative, and medicine or reagent comprising the sa

Details Bipyrazole derivative, and medicine or reagent comprising the sa Bipyrazole derivative, and medicine or reagent comprising the sa

1998-11-05

2000-09-19

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483654, A01N 4356

Patent

active

061213055

ABSTRACT:
A medicine or reagent comprising a bipyrazole derivative of the following formula (I), ##STR1## wherein R.sub.1 and R.sub.2 are individually a hydrogen atom, aryl group, alkyl group having 1-5 carbon atoms, or alkoxycarbonylalkyl group having a total of 3-6 carbon atoms, R.sub.3 and R.sub.4 are individually a hydrogen atom, alkyl group having 1-5 carbon atoms, cycloalkyl group having 5-7 carbon atoms, hydroxyalkyl group having 1-3 carbon atoms, benzyl group, naphthyl group, or substituted or unsubstituted phenyl group, as an active component. The medicine is useful for effectively capturing active oxygen and free radicals which cause adult diseases such as cerebral ischemia, heart disease, digestive system disease, and carcinoma, as well as inflammation, and for diagnosing diseases associated with in vivo free radicals.

REFERENCES:
Dael, Chemical Abstracts, vol. 125, No. 10775, 1996.
Ueda et al, Chemical Abstracts, vol. 98, No. 143319, 1983.
Croci et al, Chemical Abstracts, vol. 79, No. 65536, 1973.
Bayer, Chemical Abstracts, vol. 102, No. 56154, 1985.

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