Bipolar trans carotenoid salts and their uses

Details Bipolar trans carotenoid salts and their uses Bipolar trans carotenoid salts and their uses

2011-04-05

2011-04-05

Carr, Deborah D (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C560S190000

Reexamination Certificate

active

07919527

ABSTRACT:
The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.

REFERENCES:
patent: 2175843 (1939-10-01), Kuhn et al.
patent: 2948748 (1960-08-01), Guex et al.
patent: 3489806 (1970-01-01), Gutmann et al.
patent: 3687990 (1972-08-01), Gutmann et al.
patent: 3788468 (1974-01-01), Gainer
patent: 3853993 (1974-12-01), Gainer et al.
patent: 3965261 (1976-06-01), Gainer
patent: 3975519 (1976-08-01), Gainer
patent: 4009270 (1977-02-01), Gainer, Jr.
patent: 4038144 (1977-07-01), Gainer
patent: 4046880 (1977-09-01), Gainer
patent: 4070460 (1978-01-01), Gainer, Jr.
patent: 4105855 (1978-08-01), Schulz et al.
patent: 4176179 (1979-11-01), Gainer
patent: 4216211 (1980-08-01), Francis
patent: 5472946 (1995-12-01), Peck et al.
patent: 6060511 (2000-05-01), Gainer
patent: 6150561 (2000-11-01), Kreienbuhl et al.
patent: 7145025 (2006-12-01), Lockwood et al.
patent: 7446101 (2008-11-01), Madhavi et al.
patent: 2003/0180282 (2003-09-01), Serebruany et al.
patent: 2004/0109920 (2004-06-01), Reuscher et al.
patent: 2006/0194973 (2006-08-01), Gainer et al.
patent: 2007/0088248 (2007-04-01), Glenn et al.
patent: 2008/0255246 (2008-10-01), Gainer
patent: 522 572 (1972-06-01), None
patent: 0 908 449 (1999-04-01), None
patent: 0 908 449 (1999-04-01), None
patent: 63-059831 (1988-03-01), None
patent: A 03-056412 (1991-03-01), None
patent: A 04-264020 (1992-09-01), None
patent: 05-032531 (1993-02-01), None
patent: A 05-178765 (1993-07-01), None
patent: 7-223960 (1995-08-01), None
patent: A 07/291854 (1995-11-01), None
patent: 10-502388 (1998-03-01), None
patent: 2002-524535 (2002-08-01), None
patent: A 03-26607 (2003-01-01), None
patent: WO 92/15544 (1992-09-01), None
patent: WO 9500130 (1995-01-01), None
patent: WO 98/14183 (1998-04-01), None
patent: WO 9814183 (1998-04-01), None
patent: WO 03/072734 (2003-09-01), None
patent: WO 03/072734 (2003-09-01), None
patent: WO 2004/048323 (2004-06-01), None
patent: WO 2005/028411 (2005-03-01), None
patent: WO 2006/039685 (2006-04-01), None
patent: WO 2006/104610 (2006-10-01), None
patent: WO 2007/072529 (2007-06-01), None
Notification Concerning Transmittal of International Preliminary Report on Patentability (Chapter 1 of the Patent Cooperation Treaty), dated May 14, 2010.
International Preliminary Report on Patentability, dated May 4, 2010.
Written Opinion dated Mar. 25, 2009 in PCT/US2008/012440 [previously submitted].
Johnson, M.E., et al,Journal of Pharmaceutical Sciences, vol. 85, No. 7, pp. 670-679, Jul. 1996, “Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery.”
Holloway, G.M., et al, The American Physiological Society, 1988, pp. 683-686—Department of Chemical Engineering, and Dept. of Anesthesiology, School of Medicine, Univ. of VA, Charlotteville, Va; “The carotenoid crocetin enhances pulmonary oxygenation.”
Okonkwo, D.O., et al, Neuroscience Letters 352 (2003) 97-100, “Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation.”
Seyde, Walter C., et al, Journal of Cerebral Blood Flow and Metabolism, vol. 6, No. 6, 1986, pp. 703-707, “Carotenoid Compound Crocetin Improves Cerebral Oxygenation in Hemorrhaged Rats.”
Chinese Office Action and its English Translation dated Feb. 12, 2010 in the Assignee's Chinese application relating to PCT/US 06/06422.
Examination Report dated Apr. 7, 2010 issued by the New Zealand Patent Office in Applicants' corresponding foreign application No. 584433.
Wirz, R., et al, Helv. Chim. Acta, vol. 43, No. 6, 1960, pp. 1738-1745, (XP008042762).
Isler, O., et al, Helv. Chim. Acta, vol. 40, No. 5, 1957, pp. 1242-1249, (XP008042920).
Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; (XP002317165) [JP 63 059831].
Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, p. 6203-6214 (XP002317164).
Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; (XP002317166) [JP 05 032531].
Gibson, T.W., et al, J. Org. Chem., vol. 41, No. 5, 1976, pp. 791-793, (XP002325593).
Examination Report dated Apr. 12, 2010 issued by the India Patent Office in one of Applicants' corresponding foreign applications.
Pfander, H. et al,Pure&Appl. Chem., vol. 69, No. 10, pp. 2047-2060 (1997), “Carotenoid synthesis: A progress report.”
Widmer, Erich et al, Helvetica Chemica Acta—vol. 73 (1990), pp. 861-867, Technical Procedures for the Syntheses of Carotenoids and Related Compounds . . . .
Polish Office Action dated Feb. 23, 2010 from Polish Patent Application No. P-373780 based on PCT/US03/05521.
Australian Office Action dated Mar. 26, 2010 in applicant's Australian application No. 2003265617.
Wirz, R., et al, Helv. Chim. Acta, vol. 43, No. 6, 1960, pp. 1738-1745.
Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, pp. 6203-6214.
Chinese Office Action dated Mar. 29, 2010 from Chinese Patent Application No. 03826969.4 based on PCT/US03/26424.
Ladig et al,J. Am. Chem. Soc., 120, 9394-9395 (1998).
Japanese Office Action and its English Translation dated Apr. 6, 2010 in the Assignee's Japanese application relating to PCT/US2006/006422.
Mexican Office Action dated May 2010, and English translation of rejected parts of the Office Action, from Mexican Patent Application No. PA/a/2004/008253 corresponding to International Patent Application No. PCT/EP2003/005521.
Canadian Office Action issued Oct. 26, 2010 in corresponding Canadian Application No. 2537210.
Examination Report dated Oct. 25, 2010 issued by the Australian Patent Office in one of Applicants' corresponding foreign applications.
Norwegian Office Action and its English Translation mailed Jun. 22, 2010 in the Assignee's Norwegian application relating to PCT/US03/05521.
Wirz, R., et al, Helv. Chim. Acta, vol. 43, No. 6, 1960, pp. 1738-1745, (XP008042762).
Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; XP002317165 [JP 63 059831].
Korean Office Action and its English Translation dated Jun. 22, 2010 from applicant's Korean Patent Appln. No. 10-2006-7003827, that corresponds to PCT/US03/26424.
Ukraine Office Action issued Aug. 2010.
Written Opinion and International Search Report issued in PCT/US06/06422 dated Oct. 19, 2006.
Database HCAPLUS on STN, DN 141:388250, Magesh, V. “Studies on the anti-tumor effect of crocetin against benzo(a)pyrene induced lung cancer in Swiss albino mice.” Biomedicine, (Chennai, India) (2003), 23 (3 & 4), 96-99, Abstract.
Canadian Office Action issued Jul. 7, 2010 in corresponding Canadian Application No. 2477245.
Wirz, R., et al,Helv. Chim. Acta, vol. 43(6), pp. 1738-1745, 1960, (XP008042762).
Wenkert, E., et al,J. Org. Chem., vol. 55(25), pp. 6203-6214, 1990, (XP002317164).
RN: 33261-80-2; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-dipotassium salt.
RN: 33261-81-3; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-disodium salt.
RN: 120523-11-7; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-potassium sodium salt.
RN: 147484-59-1; CN: 2,4,6,8-Decatetraenedioic acid, disodium salt.
Examination Report dated Oct. 7, 2010 issued by the New Zealand Patent Office in one of Applicants' corresponding foreign applications.
IPRP issued in corresponding PCT Appln. No. PCT/US2008/004708.
Polish Office Action dated Sep. 2010 in corresponding Polish Application No. P-373780.
International Search Report dated Sep. 1, 2010 in PCT/US 10/01794.
Written Opinion dated Sep. 1, 2010 in PCT/US 10/01794.
Supplementary European Search Report dated Apr. 29, 2010 issued by the EPO in one of Applicants' corresponding foreign applications.
Zheng, S., et al, “Crocetin Attenuates Atherosclerosis in Hyperlipidemic Rabbits Through Inhibition of LDL Oxidation,” Journal of Cardiovascular Pharmacology, vol. 47, No. 1, Jan. 2006, pp. 70-76, XP009135396, ISSN: 0160-2446.
Supplem

Affiliated with

Also associated with

Rating

Bipolar trans carotenoid salts and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bipolar trans carotenoid salts and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bipolar trans carotenoid salts and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2718865