Biphenysulfonamide matrix metal alloproteinase inhibitors

Details Biphenysulfonamide matrix metal alloproteinase inhibitors Biphenysulfonamide matrix metal alloproteinase inhibitors

1997-04-21

1998-05-26

Barts, Samuel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514539, 560 12, 562430, A61K 3120

Patent

active

057565457

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 includes alkyl, halo, nitro, amino, cyano, alkoxy, and alkoxycarbonyl; R.sup.2 is alkyl and substituted alkyl; and R.sup.3 is OH or NHOH are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues.

REFERENCES:
patent: 3784701 (1974-01-01), Tomcufcik et al.
patent: 4269775 (1981-05-01), Szczepanski et al.
patent: 4388464 (1983-06-01), Kristinsson et al.
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4632931 (1986-12-01), Nakane et al.
patent: 4715883 (1987-12-01), Lukaszczyk et al.
patent: 5270326 (1993-12-01), Galardy et al.
Biochemistry, vol. 31, No. 45, 1992, Qi-Zhuang Ye, et al., pp. 11231-11235.
J. Med. Chem, 1993, vol. 36, No. 26, Chapman et al., pp. 4293-4301.

Affiliated with

Also associated with

Rating

Biphenysulfonamide matrix metal alloproteinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biphenysulfonamide matrix metal alloproteinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenysulfonamide matrix metal alloproteinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1960762