Biphenylylpropionic acid derivative and pharmaceutical compositi

Details Biphenylylpropionic acid derivative and pharmaceutical compositi Biphenylylpropionic acid derivative and pharmaceutical compositi

1985-06-07

1988-08-23

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560102, 549318, 514886, 514887, 514960, 514961, 514962, 514966, 514969, 514473, A61K 3122, C07C 69635

Patent

active

047661488

ABSTRACT:
Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is a lower alkyl group having 1 to 5 carbon atoms and R.sup.2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, or a lactone having the formula: ##STR3## wherein R.sup.3 and R.sup.4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.

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