Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1974-10-29
1977-11-29
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
42424856, 42424858, 424267, 424274, 424330, 544129, 544167, 544174, 260239B, 2602475G, 2602477S, 26029364, 26029369, 26029371, 26029378, 26029383, 2603265M, 2605707, C07D29508, A61K 31535
Patent
active
040606090
ABSTRACT:
Biphenylyl ethers of the formula R--O--CH.sub.2 --CR.sub.1 (OH)--CH.sub.2 Z wherein R.sub.1 is H or CH.sub.3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF.sub.3, NO.sub.2 and piperidino or, when R.sub.1 is CH.sub.3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R--O--CH.sub.2 --Y wherein Y is ##STR1## or --CR.sub.1 (OH)--CH.sub.2 X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.
REFERENCES:
patent: 3337628 (1967-08-01), Crowther et al.
patent: 3501769 (1970-03-01), Crowther et al.
Crowther et al. III, J. Med. Chem., vol. 11, pp. 1009-1013 (1968).
Kurihara et al., Chem. Abst., vol. 64, col. 12664 (1966).
Ing et al., J. Pharm. Pharmacol., vol. 4, pp. 21 to 26 (1952).
Jonas Rochus
Mehrhof Werner
Nowak Herbert
Schacht Erich
Simane Zdenek
Jiles Henry R.
Merch Patent Gesellschaft mit beschrankter Haftung
Ramsuer R. W.
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