Biphenylsulfonylcyanamides, process for their preparation, and t

Details Biphenylsulfonylcyanamides, process for their preparation, and t Biphenylsulfonylcyanamides, process for their preparation, and t

1998-09-21

1999-10-19

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514602, 514604, 558409, 558408, 564 86, 564 87, 564 88, 564 91, A61K 31275, C07C25533, C07C30929

Patent

active

059689781

ABSTRACT:
Compounds of the formula I ##STR1## in which the symbols have the meanings indicated in the claims, have outstanding antiarrhythmic properties. They exhibit a cardioprotective component. They can inhibit or greatly decrease, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a strong inhibitory action on the proliferation of cells.

REFERENCES:
patent: 5281614 (1994-01-01), Ashton et al.
patent: 5412097 (1995-05-01), Chakravarty et al.
George Wittig et al., "Methylenecyclohexane (Cyclohexane, methylene-)," Organic Syntheses, vol. 40, pp. 66-68. (1973).
Richard Greenwald, et al., "The Wittig Reaction Using Methylsulfinyl Carbanion-Dimethyl Sulfoxide," J. Org. Chem. (1963), vol. 28, pp. 1128-1129.
George Wittig et al., "Methylenecyclohexane" (Cyclohexane, methylene-), Organic Syntheses, vol. 5, (1973), pp. 751-754.
Heiner Jendralla et al., "Efficient, Simple Procedures for the Large-Scale Preparation of Building Blocks for Angiotensin (II) Receptor Antagonists," Liebigs Ann., 1995, pp. 1253-1257.

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