Biphenylmethane derivative and pharmacological use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546118, C07D47104, A61K 31435

Patent

active

053289110

ABSTRACT:
The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4870186 (1989-09-01), Aldrich et al.
patent: 4874867 (1989-10-01), Aldrich et al.
patent: 4880804 (1989-10-01), Carini et al.
patent: 4916129 (1990-04-01), Carini et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Biphenylmethane derivative and pharmacological use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biphenylmethane derivative and pharmacological use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenylmethane derivative and pharmacological use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-396621

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.