Biphenylmethane derivative and pharmacological use

Details Biphenylmethane derivative and pharmacological use Biphenylmethane derivative and pharmacological use

1992-05-01

1996-04-09

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546118, A61K 31435, C07D47104

Patent

active

055062385

ABSTRACT:
The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.
patent: 5102880 (1992-04-01), Chakravarty et al.
Chemical Abstract, vol. 94, No. 9, 2 Mar. 1981, Columbus, Ohio, Abstract No. 65554u (p. 717).
Chemical Abstract, vol. 101, No. 5, 30 Jul. 1984, Columbus, Ohio, Abstract No. 35051 (p. 220).

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