Biphenylene compounds

Details Biphenylene compounds Biphenylene compounds

2002-08-29

2008-10-07

Witherspoon, Sikarl A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S325000, C562S499000, C424S059000, C424S060000

Reexamination Certificate

active

07432400

ABSTRACT:
These are described biphenylene compounds of formula (I) wherein R1is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- or poly-substituted by hydroxy, halogen, C1-C18alkyl, C1-C18alkoxy, amino, C1-C5monoalkyamino or by di-C1-C5alkylamino; C5-C7cycloalkyl or C5-C7cycloalkenyl each unsubstituted or substituted by C1-C5alkyl; —OR′; or NR′R″; R2is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- poly-substituted by hydroxy, hadroxy, C1-C18alkoxy, amino, C1-C5monoalkylamino or by di-C1-C5alkylamino; —OR′; —NR′R″; or R1and R2together form a 5- to 7- membered monocyclic carbocyclic or heterocyclic ring; R3is hydrogen; C1-C6alkyl or C1-C6alkoxy; R′ and R″ are each independently of the other hydrogen; unsubstituted or mono- or poly-hydroxy-, halo-, C1-C18alkyl-, C1-C18alkoxy-, amino- or quaternary ammonium groupsubstituted C1-C18alkyl, C5-C7cycloalkyl or phenyl; and n is 0 or 1; wherein, when R2is OR′ or NR′R″ and n=1, R1is not simultaneously OR′; or NR′R″. The compounds according to the invention are suitable especially as sun protection agents in cosmetic, pharmaceutical and veterinary medicine preparations.

REFERENCES:
patent: 4726942 (1988-02-01), Lang et al.
patent: WO00/20384 (2000-04-01), None
Fukuda et al. Novel Seco Cyclopropa[c] pyrrolo[3,2-e] indole Bisalkylators Bearing a 3,3′-Arylenebisacryloyl Group as a Linker. Journal of Medicinal Chemistry, 2001, vol. 44, pp. 1396-1406.
N. Ganushchak et al., Journal of Organic Chemistry of the USSR, vol. 18, No. 8, (1982), pp. 1508-1512.

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