Biphenylene branched alkyleneoxy quinolines

Details Biphenylene branched alkyleneoxy quinolines Biphenylene branched alkyleneoxy quinolines

1993-08-03

1994-11-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 4, 546153, 546156, A61K 3147

Patent

active

053691148

ABSTRACT:
There are disclosed quinolines of the formula ##STR1## wherein R.sup.1 is hydrogen, or hydrocarbyl. R.sub.3 and R.sub.4 are independently, H, alkyl, various functional groups or alkylenedioxy, X is phenylene optionally bearing a substituent, R.sub.a is (1-4)C alkyl optionally bearing one or more F's, Z is various carboxyl derivatives, useful as angiotensin II antagonists.

REFERENCES:
patent: 3932416 (1976-07-01), Bays et al.
patent: 4034075 (1977-07-01), Bays et al.
patent: 4461896 (1984-07-01), Portlock
patent: 4920131 (1990-04-01), Huang et al.
patent: 4920133 (1990-04-01), Huang et al.
patent: 5028615 (1991-07-01), Huang et al.
patent: 5126344 (1992-06-01), Roberts et al.
patent: 5130318 (1992-07-01), Roberts et al.
patent: 5219863 (1993-07-01), Roberts et al.
patent: 5227387 (1993-07-01), Dreikorn et al.
patent: 5240940 (1993-08-01), Arnold et al.
patent: 5246944 (1993-09-01), Greenlee et al.
patent: 5296484 (1994-03-01), Coghlan et al.
Proctor et al. Jour Chem. Soc. Perkins Trans. vol. 1, pp. 1803-1808 (1972).
Hauser, et al. Jour. Am. Chem Soc vol. 77 p. 2852 (1955).
Raya et al. Am. Jour. of Hypertension, vol. 4 3345-3405 (1991).
Youssefyeh, R. D., et al. (principal author Huang) J. Med. Chem. (1990), 33, 1186-1194.
Huang, R-C J. Med. Chem. (1990), 33, 1194-1200.
Physician's Desk Reference, Medical Economics, Montvale, N.J. vol. 46 pp. 2255-2258 (1992).

Affiliated with

Also associated with

Rating

Biphenylene branched alkyleneoxy quinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biphenylene branched alkyleneoxy quinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenylene branched alkyleneoxy quinolines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-74330