Biphenylcarboxamides useful as lipid lowering agents

Details Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamides useful as lipid lowering agents

2007-12-04

2007-12-04

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C558S410000, C560S041000, C546S234000, C562S450000

Reexamination Certificate

active

11338282

ABSTRACT:
Biphenylcarboxamide compounds of formula (I)methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.

REFERENCES:
patent: 3910930 (1975-10-01), Janssen et al.
patent: 3929801 (1975-12-01), Janssen et al.
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4329348 (1982-05-01), Huebner
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4470989 (1984-09-01), Henning et al.
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4739073 (1988-04-01), Kathawala
patent: 4847271 (1989-07-01), Chabala et al.
patent: 5041432 (1991-08-01), Gaylor et al.
patent: 5064856 (1991-11-01), Garrity et al.
patent: 5120729 (1992-06-01), Chabala et al.
patent: 5137901 (1992-08-01), Junge et al.
patent: 5177080 (1993-01-01), Angerbauer et al.
patent: 5371094 (1994-12-01), Heine et al.
patent: 5492916 (1996-02-01), Morriello et al.
patent: 5510379 (1996-04-01), Lee et al.
patent: 5512548 (1996-04-01), Kushwaha et al.
patent: 5541199 (1996-07-01), Mewshaw
patent: 5696136 (1997-12-01), Heine et al.
patent: 5760246 (1998-06-01), Biller et al.
patent: 5827875 (1998-10-01), Dickson, Jr. et al.
patent: 5919795 (1999-07-01), Chang et al.
patent: 5965577 (1999-10-01), Tino
patent: 5968950 (1999-10-01), Quallich et al.
patent: 6133277 (2000-10-01), Wigerinck et al.
patent: 6878724 (2005-04-01), Meerpoel et al.
patent: 2004/0014971 (2004-01-01), Meerpoel et al.
patent: 2004/0019051 (2004-01-01), Van Emalen et al.
patent: 2091102 (1993-09-01), None
patent: 2091102 (1993-09-01), None
patent: 0491266 (1992-08-01), None
patent: 0 643 057 (1995-03-01), None
patent: 0645377 (1995-03-01), None
patent: 0843057 (1995-03-01), None
patent: 0845378 (2000-08-01), None
patent: 0567028 (2003-03-01), None
patent: WO93/17017 (1993-09-01), None
patent: WO95/05383 (1995-02-01), None
patent: WO96/26205 (1996-08-01), None
patent: WO96/40640 (1996-12-01), None
patent: WO98/40640 (1996-12-01), None
patent: WO98/10559 (1998-04-01), None
patent: WO98/23593 (1998-06-01), None
patent: WO98/27979 (1998-07-01), None
patent: WO98/26205 (1998-08-01), None
patent: WO98/26948 (1998-09-01), None
patent: WO99/29687 (1999-06-01), None
patent: WO99/56407 (1999-12-01), None
patent: WO 00/32532 (2000-06-01), None
patent: WO00/32582 (2000-06-01), None
patent: WO00/75136 (2000-12-01), None
patent: WO00/75137 (2000-12-01), None
patent: WO 01/77077 (2001-10-01), None
patent: WO01/77077 (2001-10-01), None
patent: WO01/98306 (2001-12-01), None
patent: WO02/20501 (2002-03-01), None
patent: WO 02/50501 (2002-03-01), None
patent: WO02/42271 (2002-05-01), None
patent: WO02/081480 (2002-10-01), None
PCT International Search Report dated Aug. 1, 2002 for PCT Application No. PCT/EP01/13316.
Sharpe, D. et al., “Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaernia.”Nature, 1993, pp. 65-69, vol. 365.
Akrakawa, T. “New Aspects of Gastric Adaptive Relaxation, Reflex after Food Intake for More Food: Involvement of Capsaicin-sensitive Sensory Nerves and Nitric Oxide.”J. Smooth Muscle Res., 1997, pp. 81-88, vol. 33.
Wetterau, J. R. et al., “An MTP Inhibitor That Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits.”Science, 1998, pp. 751-754, vol. 282.
Wiloughby, C., Chapman, K., Solid Phase Synthesis of Aryl Arnines, Tetrahedron Letters, 1996, pp. 7181-7184, vol. 37, No. 40.
Hudson, D., Methodological Implications of Simultaneous Solid-Phase Peptide Synthesis. 1. Comparison of Different Coupling Procedures, J. Org. Chem., 1988, pp. 617-624, vol. 53.
Pietzonka, T., Damon, R., Russell, M. , Wattanasin, S., Phosphonate-Containing Analogs of Cholesteryl Ester as Novel Inhibitors of Cholesteryl Ester Transfer Protein, 1996, pp. 1951-1954, vol. 6, No. 16.
Chan, D., Monaco, K. Wang, R., Winters, M., New N-and O-Arylations with Phenylboronic Acids and Cupric Acetate. Tetrahedron Letters, 1998, .pp. 2933-2936, vol. 39.
Wolfe, J., Wagaw, S, Buchwald, S., An Improved Catalyst System for Aromatic Carbon-Nitrogen Bond Formation: The Possible Involvement of Bis(phosphine) Palladium Complexes as Key Intermediates, J. Am. Chem. Soc. 1996, pp. 7215-7216, vol. 118.
Wetterau, J., Zilversmit, B. Purification and Characterization of Microsomal Triglyceride and Cholesteryl Ester Transfer Protein from Bovine Liver Microsomes, Chemistry and Physics of Lipids, vol. 38, 1985, pp. 205-222.
Sharp, D, Blinderman, L. Combs, K, Klenzie, B., Ricci, B. Wager-Smith,K, Gil, C., Turck C, Bouma, M., Rader, D, Aggerbeck, L., Gregg,R., Gordon, D, Wetterau, J., Cloning and gene defects in microsomal triglyceride transfer protein associated with a betalipoproteinaemia, Nature, vol. 385, 1993, pp. 65-69.
Kim, Y., Son, K. Name, J., Kim, S. Jeong, T. Lee, W. Bok, S. Kwon, B. Park, Y. Shin, J., Inhibition of Cholesteryl Ester Transfer Protein by Rosenonolactone Derivatives, The Journal of Antibiotics, vol. 49, No. 8, 1996, pp. 815-816.
Taylor, F. Kandutsch, A., Use of Oxygenated Stenols to Probe the Regulation of 3-Hydroxy-3-methyigiutaryl-CoA Reductase and Steroiogenesis, Methods in Enzymology, vol. 110, 1985, 9-19, Academic Press.
Miziorko, H., 3-Hydroxy-3-methylglutaryl-CoA Synthase from Chicken Liver, Methods in Enzymology, vol. 110, 1985, pp. 19-26, Academic Press.
Agnew, W., Squalene Synthetase, Methods in Enzymology, vol. 110, 1985, pp. 359-373, Academic Press.
Qureshi, N. , Nimmaniit, S., Porter, J., 3-Hydroxy-3-Methylglutaryl-CoA Reductase from Yeast, Methods in Enzymology, vol. 71, 1981, pp. 455-461, Academic Press.
Kleinsek, D., Dugan, R. Baker, D., Porter, J., 3-Hydroxy-3-Methylglutaryl-CoA Reductase from Rat Liver, Methods in Enxymology, vol. 71, 1981, pp. 462-479, Academic Press.
Rodwell, V. , Bensch, W., S-3 Hydroxy-3-Methylglutaryl-CoA Rductase from Pseudomonas, Methods in Enzymology, vol. 71, 1981, pp. 480-485, Academic Press.
Ingebritsen, T, Gibson, D., Assay of Enzymes that Modulate S-3-Hydroxy-3Methylglutaryl-CoA Reductase by Reversible Phosphorylation, Methods in Enzymology, vol. 71, 1981, pp. 486-509, Academic Press.
Mercer, E., Inhibitors of Sterol Biosynthesis and their Applications, Prog. Lipid Res., vol. 32, No. 4, 1993, pp. 357-416, Great Britain.

Affiliated with

Also associated with

Rating

Biphenylcarboxamides useful as lipid lowering agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biphenylcarboxamides useful as lipid lowering agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenylcarboxamides useful as lipid lowering agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3859064