Biphenylamido derivatives as melatonergic agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564 60, 564147, 564190, 564201, 514595, 514596, 514614, C07C23307, C07C23318, C07C23320, A61K 31165

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active

058081518

ABSTRACT:
There is provided novel biphenylamido derivatives of the formula ##STR1## wherein Z is ##STR2## and Y is H or Z is H and Y is ##STR3## n is 0 or 1; R is C.sub.1-6 alkyl;

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Arendt, et al., "Alleviation of Jet Lag by Melatonin: Preliminary Results of Controlled Double Blind Trial", British Medical Journal, 292, p. 1170 (1986).
Cassone, et al., "Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin", J. Biol. Rhythms, 1, pp. 219-229, (1986).

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