Biphenyl vasopressin agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S557000, C540S558000, C540S559000, C540S553000

Reexamination Certificate

active

10980939

ABSTRACT:
A compound of the formulae (I) or (II):wherein:Y is a moiety selected from NR or —(CH2)n;wherein R is hydrogen or (C1–C6) lower alkyl,and n is 1;represents:(1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or(2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, halogen or (C1–C6) lower alkoxy;represents:(1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1–C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1–C6) lower alkoxy, or (C1–C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1–C6) lower alkyl], —CON[(C1–C6) lower alkyl]2; or(2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, (C1–C6) lower alkoxy, or halogen; or(3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1–C6) lower alkyl, halogen, or (C1–C6) lower alkoxy;represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C1–C6) lower alkyl, halogen, or (C1–C6) lower alkoxy;R1is a moiety of the formulaand R2, R3, R7, R8and R9are, independently, selected from a group consisting of hydrogen, (C1–C3) lower alkyl, OCH3, halogen, CF3, —SCH3, OCF3, SCF3, or CN;or a pharmaceutically acceptable salt, or pro-drug form thereof.

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