Biphenyl-substituted guanidine derivatives useful as hypoglycaem

Details Biphenyl-substituted guanidine derivatives useful as hypoglycaem Biphenyl-substituted guanidine derivatives useful as hypoglycaem

1992-06-17

1994-04-12

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 56, 544165, 544330, 544402, 544 582, 544383, 544398, 546225, 546231, 546223, 546332, 5483001, 548369, 5483265, 548541, 564238, 564245, 564239, C07D21146, A61K 31445

Patent

active

053027205

ABSTRACT:
Compounds of formula I ##STR1## and their salts in which R.sub.1 is optionally substituted phenyl, R.sub.2 is alkyl, cycloalkyl or optionally substituted amino, or R.sub.2 and R.sub.3 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring and R.sub.5 is H, halo, alkyl, alkoxy, trifluoromethyl or a group of formula S(O).sub.m R.sub.8 in which m is 0, 1 or 2 and R.sub.8 is alkyl have utility in the treatment of diabetes particularly in the treatment of hyperglycaemia.

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