Biphenyl hydroxamic acids

Details Biphenyl hydroxamic acids Biphenyl hydroxamic acids

1986-06-04

1988-03-01

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

2605005H, 260545R, 558233, 560 29, 560115, 560159, 560314, 562439, 514486, 514487, 514507, 514564, 514575, C07C 8310, A61K 31265

Patent

active

047286709

ABSTRACT:
Biphenyl hydroxamic acids are provided having the structure ##STR1## wherein m is 1 to 7, X is S, O or NH, R is H, lower alkyl, aryl, aralkyl or cycloalkyl and R.sup.1 is H, lower alkyl, aryl, aralkyl, cycloalkyl, alkanoyl or aroyl.
These compounds are inhibitors of .DELTA..sup.5 -lipoxygenase and as such are useful as antiallergy agents.

REFERENCES:
patent: 3166587 (1965-01-01), Bernstein
patent: 4604407 (1986-08-01), Haslanger
Corey et al., "Rationally Designed, Potent Competitive Inhibitors of Leukotriene Biosynthesis", J. Am. Chem. Soc., 1984, 106, 1503-1504.

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