Biphenyl derivatives, process for preparing the same and interme

Details Biphenyl derivatives, process for preparing the same and interme Biphenyl derivatives, process for preparing the same and interme

1992-10-01

1993-08-03

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549442, 549436, 549362, 549350, C07D31918, C07D32110, C07D31764

Patent

active

052330575

ABSTRACT:
Novel biphenyl derivatives of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formula: ##STR2## one or two of R.sup.2 to R.sup.7 are hydrogen atom, and the remaining groups are the same or different and are each a lower alkoxy group, a phenyl(lower)alkoxy group or hydroxy group, or the adjacent two groups thereof combine to form a lower alkylenedioxy group, and Alk.sup.1 is a lower alkylene group, or a pharmaceutically acceptable salt thereof, which are useful for the prophylaxis and treatment of hepatic diseases, and processes for preparing the same, and intermediates therefor.

REFERENCES:
patent: 4849448 (1989-07-01), Kimura et al.
patent: 4904694 (1990-02-01), Matsuoka et al.
Wunsche, C. et al., "Elektronestoss-Induzierte Alkyl-Und Wasserstoffwanderungen Bei Diphensaurederivaten", Tetrahedron 24:8 (1968), pp. 3407-3416.
Zhang et al., Chemical Abstracts 92:23, Jun. 7, 1982, p. 630, No. 1992255x.
Dallacker et al., Chemical Abstracts 102:13, Apr. 1, 1985, p. 700, No. 113343g.

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