Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1997-05-12
1998-12-15
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544365, 544372, 544374, 544379, 544389, 544392, 544394, 544395, 514252, 514255, C07D40106, C07D295073, C07D295088, C07D295112
Patent
active
058499121
ABSTRACT:
A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
REFERENCES:
patent: 3381009 (1968-04-01), Palazzo et al.
patent: 3558629 (1971-01-01), Archer et al.
patent: 3692821 (1972-09-01), Sarett et al.
patent: 4125612 (1978-11-01), Sherlock
patent: 4831034 (1989-05-01), Barreau et al.
patent: 5021421 (1991-06-01), Hino et al.
patent: 5428037 (1995-06-01), Pascal et al.
Chemical Abstracts, Abstract No. 6439u, vol. 114, No. 1, (Jan. 7, 1991), Barlin et al.
Registry Handbook 1974 Suppl.: Chem. Abs. Service, ACS XP002034348 (RN: 47497-49-4, 47069-47-6).
Duncan et al, Chemical Abstracts, vol. 70, No. 47401 S (1969).
Duncan et al, J. Med. Chem. 12(1), pp. 25-29 (1969).
Zhang et al, Chemical Abstracts, vol. 106, No. 119384 (1987).
Akasaka Kozo
Higurashi Kunizo
Kajiwara Akiharu
Kitazawa Noritaka
Komatsu Makoto
Bernhardt Emily
Eisai Co. Ltd.
LandOfFree
Biphenyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biphenyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenyl derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1459442