Biphenyl compounds useful as muscarinic receptor antagonists

Details Biphenyl compounds useful as muscarinic receptor antagonists Biphenyl compounds useful as muscarinic receptor antagonists

2011-02-10

2011-11-08

Andres, Janet (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S327000

Reexamination Certificate

active

08053448

ABSTRACT:
This invention provides methods of using compounds of formula Ib below to treat pulmonary disorders.wherein:R4is hydrogen or (1-4C)alkyl;q is 0, 1, or 2;R5is independently selected from halo, (1-4C)alkyl, and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents;R7is hydrogen or (1-4C)alkyl;or a pharmaceuticallly acceptable salt thereof.

REFERENCES:
patent: 5618827 (1997-04-01), Oxford
patent: 6617325 (2003-09-01), Lehman-Lintz et al.
patent: 6635764 (2003-10-01), Mammen et al.
patent: 6656694 (2003-12-01), Mammen
patent: 6693202 (2004-02-01), Aggen et al.
patent: 7262205 (2007-08-01), Mammen et al.
patent: 7265133 (2007-09-01), Mammen et al.
patent: 7288657 (2007-10-01), Mammen et al.
patent: 7456199 (2008-11-01), Mammen et al.
patent: 7479562 (2009-01-01), Ji et al.
patent: 7491736 (2009-02-01), Mammen et al.
patent: 7501442 (2009-03-01), Mammen et al.
patent: 7521041 (2009-04-01), Mammen et al.
patent: 7524962 (2009-04-01), Mammen et al.
patent: 7550595 (2009-06-01), Mammen et al.
patent: 7560469 (2009-07-01), Mammen et al.
patent: 7569588 (2009-08-01), Mammen et al.
patent: 7585879 (2009-09-01), Mammen et al.
patent: 7629336 (2009-12-01), Ji et al.
patent: 7632847 (2009-12-01), Mu et al.
patent: 7642355 (2010-01-01), Mu et al.
patent: 7659403 (2010-02-01), Mu et al.
patent: 7683173 (2010-03-01), Ji et al.
patent: 7687519 (2010-03-01), Mu et al.
patent: 7700777 (2010-04-01), Axt et al.
patent: 7728144 (2010-06-01), Ji et al.
patent: 7816532 (2010-10-01), Mammen et al.
patent: 7851631 (2010-12-01), Mammen et al.
patent: 7858797 (2010-12-01), Mammen et al.
patent: 2003/0018019 (2003-01-01), Meade et al.
patent: 2004/0167167 (2004-08-01), Mammen et al.
patent: 2004/0209860 (2004-10-01), Mammen et al.
patent: 2004/0209915 (2004-10-01), Mammen et al.
patent: 2005/0113417 (2005-05-01), Mammen et al.
patent: 2008/0071088 (2008-03-01), Mammen et al.
patent: 2009/0018165 (2009-01-01), Mammen et al.
patent: 2009/0226379 (2009-09-01), Mammen et al.
patent: 2010/0021395 (2010-01-01), Axt et al.
patent: 2010/0041701 (2010-02-01), Ji et al.
patent: 2010/0048622 (2010-02-01), Axt et al.
patent: 2010/0093753 (2010-04-01), Mu et al.
patent: 2010/0137325 (2010-06-01), Ji et al.
patent: 2010/0249421 (2010-09-01), Mammen et al.
patent: 2010/0256185 (2010-10-01), Axt et al.
patent: 0 747 355 (1996-12-01), None
patent: WO 95/06635 (1995-03-01), None
patent: WO 99/64043 (1999-12-01), None
patent: WO 01/42212 (2001-06-01), None
patent: WO 02/051841 (2002-07-01), None
patent: WO 2004/012684 (2004-02-01), None
U.S. Appl. No. 12/938,539, Mammen et al.
U.S. Appl. No. 12/956,143, Ji et al.
Broadley et al., “Muscarinic Receptor Agonists and Antagonists”, Molecules, 6, pp. 142-193 (2001).
Eglen et al., “Muscarinic Receptor Subtypes:Pharmacology and Therapeutic Potential”, DN&P, 10(8), pp. 462-469 (1997).
Hcaplus 129:58129a, “Selective muscarinic antagonists. II Synthesis and antimuscarinic properties of biphenylcarbamate derivatives”, Naito et al.
Naito et al., “Selective Muscarinic Antagonist. II.1)Synthesis and Antimuscarinic Properties of Biphenylylcarbamate Derivatives”, Chem. Pharm. Bull. , vol. 46, No. 8, pp. 1286-1294 (1998).
Patani et al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, pp. 3147-3176.
Ziedalski et at., “Advances in the Management of Chronic Obstructive Pulmonary Disease”, Expert Opin,. Pharmacother. 4(7):1063-1082 (2003).
Zlotos et al., “Muscarinic receptor agonists and antagonists”, Exp. Opin. Ther. Patents, 9(8), pp. 1029-1053 (1999).

Affiliated with

Also associated with

Rating

Biphenyl compounds useful as muscarinic receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biphenyl compounds useful as muscarinic receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biphenyl compounds useful as muscarinic receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4308156