Biphenyl compound selective agonists of gamma RAR receptors

Details Biphenyl compound selective agonists of gamma RAR receptors Biphenyl compound selective agonists of gamma RAR receptors

2008-06-16

2011-11-01

Puttlitz, Karl J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S466000, C514S533000

Reexamination Certificate

active

08049034

ABSTRACT:
Biphenyl compounds having the formula (I):are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

REFERENCES:
patent: 6316009 (2001-11-01), Bernardon et al.
patent: 2007/0021473 (2007-01-01), Biadatti et al.
patent: WO 99/10308 (1999-03-01), None
patent: WO 2005/056516 (2005-06-01), None
Marcia I. Dawson, et al. “4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl] benzoic Acid and Heterocyclic-Bridged Analogues are Novel Retinoic Acid Receptor Subtype and Retinoid X Receptor α agonists”, Bioorganic & Medicinal Chemistry Letters 10 (2000) pp. 1311-1313.

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