Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd

Details Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd

1989-07-19

1990-09-11

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Process involving micro-organisms of different genera in the...

435 681, 435108, 435146, 435171, 435254, 435255, 435832, 435911, 435923, C12R 1645, C12R 173, C12P 2100, C12P 3900

Patent

active

049562797

ABSTRACT:
Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.

REFERENCES:
patent: 4407953 (1983-10-01), DeZeeuw et al.
patent: 4628033 (1986-12-01), DeZeeuw
patent: 4877728 (1989-10-01), Bigelis et al.
Derwent Abstract 87-129791/19 (DD-242055) Jan. 1987.
Chem Abstract 88(19) 133020V Yuasa et al. (1978).
Chem Abstract 107(17) 152919X Schellenberger et al. (DD242055).
Derwent Abstract 78-53567A/30 Behrens et al. (DD-130046) Mar. 1978.

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