Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd

Details Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihyd

1988-03-28

1989-10-31

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 42, 435 69, 435108, 435146, 435171, 435911, C12P 2100, C12P 2106, C12P 742

Patent

active

048777285

ABSTRACT:
Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.

REFERENCES:
patent: 3551438 (1970-12-01), Oediger et al.
patent: 4182720 (1980-01-01), Renfrew et al.
patent: 4479803 (1984-10-01), Bachmann et al.
Derwent Abs. 87-129791/19 DD-242055, 1-87.
CA 88(19) 133020v Yuasa et al., 1978.
CA 107(17) 152919x Schellenberger et al., DD-242055.
CA 99(1) (4028) Iske et al., Acta Biotech 3(2) 14353 (1983).
Japio Derwent Abs. 80-023976 J55023976, Abe et al., 2-1980.
Derwent Abs. 66-26907f/00 J69006633, Taked Chem, 1968.
Derwent Abs. 80-24274c/14, BioRes J55023976, 2-1980.
Derwent Abs. 78-535676a/30 DD-130046, 3-1976.
Bassel et al., J. Bacteriol., 123 (1), 1975, pp. 118-122 "Mutant of the Yeast Saccharomycopsis Lipolytica that Accumulates and Excretes Protoporphyrin IX".
Yoshizaki et al., Agric. Biol. Chem., 49 (3), 1985, pp. 877-879, "The Formation of 2,6-Dihydroxyphenylacetic Acid from Phenylacetic Acid by Various Fungi".
Neuberger et al., Biochem. J., 41, 1947, pp. 438-449, "Studies on Alcaptonuria-2, Investigations on a Case of Human Alcaptonuria."
Neuberger and Webster, Biochem. J., 41, 1947, pp. 449-457, "Studies on Alcaptonuria-3., Experimental Alcaptonuria in Rats."
Morrissey, J. H., J. Gen. Microbiol., 129, pp. 1127-1132--"Deficiency in Homogentisic Acid Oxidase Activity Associated with the Brown Phenotype of Dictyostelium Discoideum".
Katz & Sussman, Proc. Nat. Acad. Sci. U.S.A., 69, pp. 495-498, 1972, "Parasexual Recombination in Dictyostelium Discoideum: Selection of Stable Diploid Heterozygotes and Stable Haploid Segregants".
Sussman & Sussman, J. Gen. Microbiol., 30, pp. 349-355, 1963, "Ploidal Inheritance in the Slime Mould Dictyostelium Discoideum: Haploidization and Genetic Segragation of Diploid Strains".

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