Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-04-02
1989-09-19
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
436 92, C07D51900
Patent
active
048683116
ABSTRACT:
The present invention provides a compound having the formula ##STR1## wherein Y is biotin or iminobiotin, X is CH.sub.2, P is psoralen or a psoralen derivative, r is an integer equal to or greater than 2 and s is an integer equal to or greater than 1.
The invention also provides a method for preparing a biotinylated psoralen or a biotinylated psoralen derivative.
Further provided are methods for detecting, purifying, and isolating nucleic acids, and methods for delivering an iminobiotinylated psoralen to a cell.
REFERENCES:
patent: 4582789 (1986-04-01), Sheldon et al.
Pierce Chemical Co., 1986-1987 Handbook, p. 305.
W. Saffran et al., Proc. Natl. Acad. Sci., USA, 79: 4594-4578 (1982).
Cantor Charles R.
Edelson Richard L.
Gasparro Francis P.
Saffran Wilma A.
Welsh John T.
Schwartz Richard A.
The Trustees of Columbia University in the City of New York
White John P.
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