Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1995-03-16
1998-04-14
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
514 2, 514 8, 514 52, 530409, 536 264, 536 2641, 5483037, A61K 3170, A61K 3816, C07H 2300, C07K 1113
Patent
active
057392870
ABSTRACT:
A biotinylated cobalamin, formed from a vitamin B.sub.12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B.sub.12 molecule is cyanocobalamin. The biotin molecule can also be coupled to a rerouting moiety, optionally through a biotin binding protein such as avidin or streptavidin. The biotinylated cobalamin binds to a cell surface receptor, is invaginated, and once internalized affects the receptor trafficking pathway.
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Morgan, Jr. A. Charles
Pathare Pradip M.
Wilbur D. Scott
Receptagen Corp.
Russel Jeffrey E.
University of Washington
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