Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-03-31
1998-09-15
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483041, 424 149, 424 9362, 424 9363, A61K 3141, C07D23500
Patent
active
058078797
ABSTRACT:
The present invention provides biotinylated compounds useful for delivering a molecule to a target site, and methods of making biotinylated compounds. The biotinylated compounds are covalent conjugates of biotin and a diagnostic or therapeutic agent, and are stable to rapid degradation by biotinidase. The compounds of the invention are useful for delivering therapeutic or diagnostic agents to target-bound streptavidin or avidin conjugated cell-targeting agents, including monoclonal antibodies. The compound N-cysteinyl biotin is also provided.
REFERENCES:
patent: 2519530 (1950-08-01), Wolf et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4680338 (1987-07-01), Sundoro et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4888163 (1989-12-01), Kubodera et al.
patent: 4943427 (1990-07-01), Yazaki et al.
patent: 5504091 (1996-04-01), Molnar-Kimber et al.
patent: 5578287 (1996-11-01), Theodore et al.
Hnatowich et al. (1987) "Investigations of Avidin and Biotin for Imaging Applications", J. Nucl. Med. 28, 1294-1302. Aug.
Kalofonos et al. (1990) "Imaging of Tumor in Patients with Indium-111-Labeled and Streptavidin-Conjugated Antibodies: Preliminary Communication", J. Nucl. Med. 31, 1791-196. Nov.
Ohmono et al. (1982) ".sup.67 Ga-Labeled Human Fibrinogen: A New Promising Thrombus Imaging Agent", Eur. J. Nucl. Med. 7, 458-461. (.delta.).
Paganelli et al. (1988) "In vivo Labelling of Biotinylated Monoclonal Antibodies by Radioactive Avidin: A Strategy to Increase Tumor Radiolocalization", Int. J. Cancer 2, 121-125. (Month Not Available).
Parker (1990) "Tumour Targeting", Chemistry in Britain, 942-945. Oct.
Rosebrough (1993) "Plasma Stability and Pharmacokinetics of Radiolabelled Deferoxamine-Biotin Derivatives", J. Pharmacol. Exp. Ther. 265, 408. (Month Not Available ).
Takahashi et al. (1985) "Preparation and Biodistribution of .sup.67 Ga-Labelled Fibrinogen Conjugated with a Water-Soluble Polymer Containing Deferoxamine", Vienna IAEA, 471-482. (Month Not Available).
Weiner et al. (1979) "Relative Stability of In-111 and Ga-67 Desferrioxamine and Human Transferrin Complexes", Proceedings of the Second International Symposium on Radiopharmaceuticals, 331-340. Mar.
Yamamoto et al. (1988) "Positive Imaging of Venous Thrombi and Thromboemboli with Ga-67 DFO-DAS-Fibrinogen", Eur. J. Nucl. Med. 14, 60-64. (Month Not Available).
Yokoyama et al. (1982) "Deferoxamine, A Promising Bifunctional Chelating Agent for Labeling Proteins with Gallium: Ga-67 DF-HSA: Concise Communication", J. Nucl. Med. 23, 909-914. (Month Not Available).
R. Blankenburg et al., Biochemistry, vol. 28, No. 20, @ 1989, pp. 8214-8221.
MacLean et al., J. Chem. Soc. Commun. (1992), 18, pp. 1283-1285.
Ebato et al., Angew. Chem., Int. Ed. Engl. (1992), 31(8), pp. 1087-1090.
Kay et al., Biochem. J. (1992), 283(2), pp. 455-459.
Darst et al., Biophys. J. (1991), 59(2), pp. 387-396.
Bladon et al., Tetrahedron Lett. (1989), 30(11), pp. 1401-1404.
Shao et al., Biochemistry (1989), 28(9), pp. 4077-4083.
Fisher et al. (CA 108:108663), 1988.
Shao et al., J. Biol. Chem. (1987), 262(7), pp. 2968-2972.
Chen et al., Biochemistry (1986), 25(4), 939-944.
Wright et al., J. Amer. Chem. Soc., vol. 73, Sep. 1951, pp. 4144-4145.
Fisher, et al. "Synthetic Inhibitors of Carboxypeptidase N", Adv. Exp. Med. Biol. (1986) pp. 405-410.
Ramsuer Robert W.
Stockton Laura L.
University of Rochester
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