Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1996-05-13
2000-01-18
Chan, Christina Y.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D25702
Patent
active
060158972
ABSTRACT:
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. Biotinamido-N-methylglycyl-seryl-O-succinamido-benzyl DOTA is disclosed.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4867962 (1989-09-01), Abrams
patent: 4902502 (1990-02-01), Nitecki et al.
patent: 5089261 (1992-02-01), Nitecki et al.
patent: 5171563 (1992-12-01), Abrams et al.
patent: 5183660 (1993-02-01), Ikeda et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5342940 (1994-08-01), Ono et al.
patent: 5556982 (1996-09-01), Fritzber et al.
J. Haensler et al, "Synthesis and Characterization of a Trigalactosylated Bisacridine Compound to Target DNA to Hepatocytes", Bioconjugate Chem. vol. 4, No. 1, pp. 85-93 (1993).
Mauk et al, "Targeting of Lipid vesicles: Specificity of carbohydrate receptor analogues for leukocytes in mice", Proc. Natl. Acad. Sci. USA, vol. 77, pp. 4430-4434 (1980).
Ponpipom et al, "Cell-Specific Ligands for Selective Drug Delivery to Tissues and Organs", J. Med. Chem., vol. 24, No. 12, pp. 1388-1395 (1981).
Schnaar et al, "Adhesion of Chicken Hepatocytes to Polyacrylamide Gels Derivatized with N-Acetylglucosamine", Journal of Biological Chemistry, vol. 253, No. 21, Nov. 10, 1978, pp. 7940-7951.
Ponpipom et al, "Cell surface carbohydrates for targeting studies", Can. J. Chem., 58, 214 (1980).
Weigel, "GlycoConjugates Composition, Structure and Function", "Chapter 14, Mechanisms and Control of Glycoconjugates Turnover", edited by Allen et al, Marcel Dekker, Inc., NY, pp. 421-497 (1992).
Weigel, "Endocytic Components: Identification and Characterization", Subcellular Biochemistry, vol. 19, Chapter 5, Endocytosis and Function of the Hepatic Asialoglycoprotein Receptor, edited by Bergeron et al, New York, pp. 125-161 (1993).
Hubbard et al, "Suppression of the Anti-DNP IgE Response with Tolerogenic Conjugates of DNP with Polyvinyl Alcohol", J. of Immunology, vol. 126, No. 2, Feb. 1981 pp. 407-413.
Chen et al, "Properties of Two Urate Oxidases Modified by the Covalent Attachment of Poly(ethylene Glycol)", Biochimica et Biophysica Acta., 660 pp. 293-298 (1981).
Savoca et al, "Preparation of a Non-Immunogenic Arginase by the Covalent Attachment of Polyethylene Glycol", Biochimica et Biophysica Acta, 578, pp. 47-53 (1979).
Lee et al, "Abrogation of the Antibenzylpenicilloyl (BPO) IgE Response with BPO-Polyvinyl Alcohol Conjugates", Int. Archs Allergy appl. Immun., vol. 63, pp. 1-13 (1980).
Lee et al, "Suppression of Reaginic Antibodies with Modified Allergens", Int. Archs Allergy appl. Immun., vol. 56, pp. 159-170 (1978).
Davis et al, "Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol", Clin. exp. Immunol., vol. 46, pp. 649-652 (1981).
Ling et al, "A General Study of the Binding and Separation in Partition Affinity Ligand Assay. Immunoassay of .beta..sub.2 -Microglobulin", J. Immunological Methods, vol. 59, pp. 327-337 (1983).
Abuchowski et al, "Alteration of Immunological Properties of Bovine Serum Albumin by Covalent Attachment of Polyethylene Glycol", J. of Biological Chem., vol. 252, No. 11, pp. 3578-3581 (1977).
Abuchowski et al, "Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates", Can. Biochem Biophys., vol. 7, pp. 175-186 (1984).
Beauchamp et al, "A New Procedure for the Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and .alpha..sub.2 -Macroglobulin", Analytical Biochem., vol. 131, pp. 25-33 (1983).
Leonard et al, "Synthesis of monomethoxypolyoxyethylene-Bound haemoglobins", Tetrahedron, vol. 40, No. 9, pp. 1581-1584 (1984).
Mauk et al, "Vesicle Targeting: Timed Release and Specificity for Leukocytes in Mice by Subcutaneous Injection", Science, vol. 207, No. 18, Jan. 1980 pp. 309-311.
J. Mattes, J. Natl. Canc. Instit., "Biodistribution of Antibodies After Intraperitoneal or Intravenous Injection and Effect of Carbohydrate Modifications", vol. 79, No. 4, Oct. 1, 1987, pp. 855-863.
Peter van der Sluijs et al, Hepatology, "Drug Targeting to the Liver and Lactosylated Albumins: Does the Glycoprotein Target the Drug or is the Drug Targeting the Glycoprotein?", vol. 6, No. 4, (1986), pp. 723-728.
G. Paganelli, Nucl. Med. Comm., "Monoclonal Antibody Pretargetting Techniques for Tumor Localization: The Avidin-Biotin System", vol. 12, (1991), pp. 211-234.
F. Virzi et al, Nucl. Med. Biol., "New Indium-111 Labeled Biotin Derivatives for Improved Immunotargeting", vol. 18, No. 7, pp. 719-726 (1991).
R. T. Lee et al, Glycoconjugate, "Preparation of Cluster Glycosides of N-Acetylgalactosamine That Have Subnanomolar Binding Constants Towards the Mammalian Hepatic Gal/GalNAc-specific Receptor", vol. 4, (1987), pp. 317-328.
R. T. Lee et al, Biochemistry, "New Synthetic Cluster Ligands for Galactose/N-Acetylgalactosamine-Specific Lectin of Mammalian Liver", vol. 23, (1984), pp. 4255-4261.
J. R. Merwin et al, Bioconjugate Chem., "Targeted Delivery of DNA Using YEE(GalNAcAH).sub.3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor", vol. 5 (1994), pp. 612-620.
M. A. Findeis, Int. J. Peptide Protein Res., "Stepwise synthesis of a GalNAc-containing cluster glycoside ligand of the asialoglycoprotein receptor", vol. 43, (1994), pp. 477-485.
T. D. McKee et al, Bioconjugate Chem., "Preparation of Asialoorosomucoid-Polylysine Conjugates", vol. 5, (1994), pp. 306-311.
E. A. L. Biessen et al, J. Med. Chem., "Synthesis of Cluster Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor", vol. 38, No. 9, (1995), pp. 1538-1546.
Marshall et al, British Journal of Cancer, "Galactosylated streptavidin for improved clearance of biotinylated intact and F(ab').sub.2 fragments of an anti-tumour antibody", 71:18-24 (1995).
Marshall et al, British Journal of Cancer, "Clearance of circulating radio-antibodies using streptavidin or secone antibodies in a xenograft model", 69:502-507 (1994).
Marshall et al, British Journal of Cancer, "Polyethylene glycol modification of a galactosylated streptavidin clearing agent: effects on immunogenicity and clearance of a biotinylated anti-tumour antibody", 73:565-572 (1996).
Samuel Zalipsky, "Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates", Reviews, American Chemical Society, Bioconjugate Chem., 1995, vol. 6, pp. 150-165.
I.S. Krull et al, J. of Chromatography B: Biomedical Applications, "Solid-phase derivatization reactions for biomedical liquid chromatography" pp. 19-50 (1994).
Merriam-Webster's Collegiate Dictionary, Tenth Edition, Merriam-Webster, Inc., Springfield, MA, p. 95, 1996.
Paganelli, G. et al. Nuclear Medicine Comm. 12: 211-234, 1991.
Richey, H. G. Fundamentals of Organic Chemistry, Prentice-Hall, Inc., Engelwood NJ, p. 324, 1983.
Axworthy et al., "Antibody Pretargeting For Radioimmunotherapy: A Three-Step Approach In Tumored Nude Mice," The Journal Of Nuclear Medicine; Proceedings Of The 39.sup.th Annual Meeting 33: p. 880, Abstract No. 234, 1992.
Galli et al., "A Radiopharmaceutical For The Study Of The Liver: .sup.99m Tc-DTPA-ASIALO-OROSOMUCOID. II: Human Dynamic and Imaging Studies," The Journal Of Nuclear Medicine And Allied Sciences 32: 117-126, 1988.
Goodwin, "New Methods for Localizing Infection: A Role for Avidin-Biotin," The Journal of Nuclear Medicine 33(10): 1816-1818, 1992.
Sanderson et al., "Preparation And Characterization Of Biotin Conjugates Of Anti-Pan-Carcinoma NR-LU-10 Monoclonal Antibody For A Three Step Radioimmunotherapy," The Journal Of Nuclear Medicine; Proceedings Of The 39.sup.th Annual Meeting 33: p. 880, Abstract No. 233, 1992.
Gustavson Linda M.
Kasina Sudhakar
Reno John M.
Theodore Louis J.
Chan Christina Y.
Gambel Phillip
NeoRx Corporation
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