Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-04-11
2006-04-11
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S007500, C435S007720, C524S313000
Reexamination Certificate
active
07026135
ABSTRACT:
Disclosed is a compound of Formula (I), wherein: L is a linking agent; B is a binding agent; X is an atom or group suitable for attaching L to the glycerol chain; and R is a straight chain saturated or unsaturated alkyl group having from 8 to 30 carbon atoms, substituted with M′ or M″ wherein at least one of M′ and/or M″ is a detectable label. The compound can be used as a lipase substrate in a solid phase-based assay system, such as a scintillation proximity assay, to detect lipase enzyme activity.
REFERENCES:
patent: WO 91/08489 (1991-06-01), None
patent: WO 99/02186 (1999-01-01), None
M. Duque, et al. “New fluorogenic triacylglycerol analogs as substrates for the determination and chiral discrimination of lipase activities” Journal of Lipid Research vol. 37, No. 4, 1996 pp. 868-876.
P. Nilsson-Ehle, et al. “A Stable Radioactive Substrate Emulsion for Assay of Lipo Protein Lipase” Journal of Lipid Research vol. 17, No. 5, 1976 pp. 536-541.
Fowler Anne
Hawes Calvin Richard
James David Martin
Poulsen Fritz
Price-Jones Molly Jean
Amersham Biosciences UK Limited
Hanley Susan
Ji Yonggang
Ronning, Jr. Royal N.
Witz Jean C.
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