Biotin containing C-glycoside nucleic acid labeling compounds

Details Biotin containing C-glycoside nucleic acid labeling compounds Biotin containing C-glycoside nucleic acid labeling compounds

2005-03-08

2005-03-08

McKenzie, Thomas (Department: 1624)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S025100

Reexamination Certificate

active

06864059

ABSTRACT:
Nucleic acid labeling compounds including the following structure are disclosed:wherein A is a triphosphate group with apporpriate counterions, said counterions selected from the group consisting of H+, Na+, Li+, K+, and NH4+; X is O; Y is OH; Z is OH; L is selected from the group consisting of —CH═CH—C(O)—NH—CH2—CH2—NH—C(O)— and —CH2—CH2—C(O)—NH—CH2—CH2—NH—C(O); M is —(CH2)45—NH—, n is 1 and Q is biotin having the structure:The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.

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