Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Patent
1996-10-02
1998-02-10
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
424 173, 424 165, 424 936, 424114, 534 14, 534 15, 514387, 514 45, 5483027, 5483041, 5483037, A61K 5100, A61K 3500, A01N 4350, C07D23502
Patent
active
057165947
ABSTRACT:
Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.
REFERENCES:
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 5135736 (1992-08-01), Anderson et al.
patent: 5219764 (1993-06-01), Huber et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5476644 (1995-12-01), Illig et al.
Garlick, R.K. and R.W. Giese, "Avidin Binding of Radiolabeled Biotin Derivatives", J. Biological Chemistry, vol. 263, No. 1, pp. 210-215 (5 Jan. 1988);.
Hnatowich, D.J., et al., "Investigations of Avidin and Biotin for Imaging Applications", J. Nuclear Medicine, vol. 28, No. 8, pp. 1294-1302 (Aug. 1987):.
Hoffman, K. and Y. Kiso, "An approach to the targeted attachment of peptides and proteins to solid supports" Proc. Natl. Acad. Sci. USA, vol. 73, No. 10, pp. 3516-3518 (Oct. 1976);.
International Search Report for PCT/US95/07184 issued 13 Oct. 1995;.
Kalofonos, H.P., et al., "Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication" Journal of Nuclear Medicine, vol. 31, No. 11, pp. 1791-1796, (Nov. 1990);.
Koch, P. and H.R. Macke, ".sup.99m Tc Labeled Biotin Conjugate in a Tumor `Pretargeting` Approach with Monoclonal Antibodies" Angewandte Chemie. Internatl. Ed., vol. 31, No. 11., pp. 1507-1509 (1 Nov. 1992);.
Shoup, T.M., et al. "The Evaluation of F-18 Labelled Biotin Derivatives for Tumor Localization with PET" J. Nuclear Medicine, vol. 33, No. 5, p. 1026, Abstract No. 853 (May 1992);.
Shoup, T.M., et al., "Synthesis and Evaluation of .sup.18 F-Labelled Biotin Derivatives for Tumor Localization with Pet" IXth International Symposium on Radiopharmaceutical Chemistry, Paris, 6-10 Apr. 1992;.
Shoup, T.M., et al., "Synthesis of Flourine-18-Labeled Biotin Derivatives: Biodistribution and Infection Localization" J. Nuclear Medicine, vol. 35, No. 10, pp. 1685-1690 (1994);.
Zhang, Z., et al. "Preparation of phototobin-DNA probes and their use for detection of Plasmodium falciparum DNA" Chemical Abstracts, vol. 113, No. 15, Abstract No. 128783 (8 Oct. 1990).
Babich John W.
Elmaleh David R.
Fischman Alan J.
Shoup Timothy M.
Hartley Michael G.
Hollinden Gary E.
The JMDE Trust
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