Biotin compounds for targetting tumors and sites of infection

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 173, 424 165, 424 936, 424114, 534 14, 534 15, 514387, 514 45, 5483027, 5483041, 5483037, A61K 5100, A61K 3500, A01N 4350, C07D23502

Patent

active

057165947

ABSTRACT:
Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.

REFERENCES:
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 5135736 (1992-08-01), Anderson et al.
patent: 5219764 (1993-06-01), Huber et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5476644 (1995-12-01), Illig et al.
Garlick, R.K. and R.W. Giese, "Avidin Binding of Radiolabeled Biotin Derivatives", J. Biological Chemistry, vol. 263, No. 1, pp. 210-215 (5 Jan. 1988);.
Hnatowich, D.J., et al., "Investigations of Avidin and Biotin for Imaging Applications", J. Nuclear Medicine, vol. 28, No. 8, pp. 1294-1302 (Aug. 1987):.
Hoffman, K. and Y. Kiso, "An approach to the targeted attachment of peptides and proteins to solid supports" Proc. Natl. Acad. Sci. USA, vol. 73, No. 10, pp. 3516-3518 (Oct. 1976);.
International Search Report for PCT/US95/07184 issued 13 Oct. 1995;.
Kalofonos, H.P., et al., "Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication" Journal of Nuclear Medicine, vol. 31, No. 11, pp. 1791-1796, (Nov. 1990);.
Koch, P. and H.R. Macke, ".sup.99m Tc Labeled Biotin Conjugate in a Tumor `Pretargeting` Approach with Monoclonal Antibodies" Angewandte Chemie. Internatl. Ed., vol. 31, No. 11., pp. 1507-1509 (1 Nov. 1992);.
Shoup, T.M., et al. "The Evaluation of F-18 Labelled Biotin Derivatives for Tumor Localization with PET" J. Nuclear Medicine, vol. 33, No. 5, p. 1026, Abstract No. 853 (May 1992);.
Shoup, T.M., et al., "Synthesis and Evaluation of .sup.18 F-Labelled Biotin Derivatives for Tumor Localization with Pet" IXth International Symposium on Radiopharmaceutical Chemistry, Paris, 6-10 Apr. 1992;.
Shoup, T.M., et al., "Synthesis of Flourine-18-Labeled Biotin Derivatives: Biodistribution and Infection Localization" J. Nuclear Medicine, vol. 35, No. 10, pp. 1685-1690 (1994);.
Zhang, Z., et al. "Preparation of phototobin-DNA probes and their use for detection of Plasmodium falciparum DNA" Chemical Abstracts, vol. 113, No. 15, Abstract No. 128783 (8 Oct. 1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Biotin compounds for targetting tumors and sites of infection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biotin compounds for targetting tumors and sites of infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biotin compounds for targetting tumors and sites of infection will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2074839

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.