Biotin biosynthetic genes

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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Details

4353201, 536 231, C12N 122, C12N 1500, C07H 2102

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active

061176699

ABSTRACT:
The present invention relates to the production process of biotin by fermentation using a genetically engineered microorganism, and DNA sequences and vectors to be used in such process.

REFERENCES:
patent: 5096823 (1992-03-01), Gloeckler et al.
Cleary et al., "Deletion and Complementation Analysis of the Biotin Gene Cluster of Escherichia Coli", J. Bacterial., 112:830-839 (1972).
Barker et al., "Use of bio-lac Fusion Strains to Study Regulation of Biotin Biosyntehsis in Escherichia Coli", J. Bacterial., 143:789-800 (1980).
Tanaka et al., "Site-Specific In vitro Binding of Plasmid pUb110 to Bacillus subtilis Membrane Fraction", J. Bacteriol., 154:1184-1194 (1983).
Otsuka et al., "The Escherichia coli Biotin Biosynthetic Enzyme Sequences Predicted from the Nucleotide Sequence of the bio Operon", J. Biol. Chem., 263:19577-19585 (1988).
M. Smith, "In vitro Mutagenesis", Ann. Rev. Genet 19:423-462 (1985).
Haima et al., "The effect of restriction on shotgun cloning and plasmid stability in Bacillus subtilis Marburg", Mol. Gen. Genet., 209:335-342 (1987).
Maniatis et al., "Transformation of Escherichia Coli by Plasmid DNA", Molecular Cloning, Cold Spring Harbor Laboratory Press, pp. 252-253, (1982).
Derwent Abstract No. 86-216622 of Japanese Patent Kokai 149091/1986.
Derwent Abstract No. 87-231579 of Japanese Patent Kokai 155081/1987.
Derwent Abstract No. 90-226023 of Japanese Patent Kokai 180174/1991.
Derwent Abstract No. 90-072971 of Japanese Patent Kokai 27980/1990.
Derwent Abstract No. 91-358298 of Japanese Patent Kokai 240489/1991.
U.S. application No. 08/833,411, Hoshino et al., filed Apr. 4, 1997, pending.
U.S. application No. 08/840,059, Hoshino et al., filed Apr. 24, 1997, pending.
Derwent Abstract of EP 375 525.

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