Biotin amides able to control glucidic metabolisms under dysmeta

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5483037, 5483041, A61K 31415

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active

058146504

ABSTRACT:
Described herein are biotin amides which are able to control glucidic metabolism under dysmetabolic conditions and relative therapeutical compositions for the treatment of insulin-independent diabetes, insulin-dependent diabetes and relative complicating diseases, such as peripheral neuropathies and other associated chronic invalidating disorders.

REFERENCES:
patent: 2519530 (1950-08-01), Wolf et al.
patent: 4054740 (1977-10-01), Field
patent: 4709037 (1987-11-01), Sigler
patent: 4908453 (1990-03-01), Cocuzza
Green, N.M.; Konieczny, L.; Toms, E.J. and Valentine, R.C. Biochem. J. (1971) vol. 125, pp. 781-791.
Jasbir Chauhan and Krishnamurti Dakshinamurti, Transcription Regulation of the Glucokinase Gene by Biotin in Starved Rats, The Journal of Biological Chemistry, vol. 266, No. 16, Jun. 1991, pp. 10035-10038.
John C. Coggeshall et al, Biotin Status and Plasma Glucose in Diabetics, N.Y. Acad. Sci. 447, 1985, pp. 389-392.
A. Reddi et al, Biotin Supplementation Improves Glucose and Insulin Tolerances in Genetically Diabetic KK Mice, Life Sciences, vol. 42, 1988, pp. 1323-1330.
Roth, Karl S., Biotin in Clinical Medicine--A Review, The American Journal of Clinical Nutrition 34: Sep. 1981, pp. 1967-1974.
Krishnamurti Dakshinamurti and Jasbir Chauhan, Biotin, Vitamins and Hormones, vol. 45, 1989, pp. 337-385.
K. Dakshinamurti and C. Cheah-Tan, Biotin-Mediated Synthesis of Hepatic Glucokinase in the Rat, Archives of Biochemistry and Biophysics 127, 1968, pp. 17-21.
D. Koutsikos et al, Biotin for Diabetic Peripheral Neuropathy, Biomed & Pharmacother, 1990, 44, pp. 511-514.
Thomas Kempe et al, Chemical and Enzymatic Biotin-Labeling of Oligodeoxyribo-nucleotides, Nucleic Acids Research, vol. 13, No. 1, 1985, pp. 45-57.
Marlon M. Bradford, A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding, Analytical Biochemistry 72, 1976, pp. 248-254.
Hanssen et al, "Diabetic Control and Microvascular Complications: The Near-Normoglycaemic Experience", Diabetologia 29: 677-684 (1986).
Chapter 34 in "Remington's Pharmaceutical Sciences" (The Philadelphia College of Pharmacy and Science, 1990) pp. 682-683.
Shami et al, "Microangiopathy in Diabetes Mellitus: II Features, Complications and Investigation", Diabetes Research, 17, 157-158 (1991) pp. 157-168.
Chapter 2.20 in Vogel's Textbook of Practical Organic Chemistry, Fifth Ed., Longman Group UK, 1989) pp. 135-136.
"Peripheral Neuropathies", World Health Organization (WHO), Technical Report Series 654 (1980), pp. 88-93.
Krishnamurti Dakshinamurti et al, "Biotin" in Vitamins and Hormones Advances in Research and Applications, vol. 45, Ed. by Aurbach and McCormick, Academic Press, Inc. (1989), pp. 337-384.
Patent Abstracts of Japan, vol. 4, No. 85 (C-015) 18 Jun. 1980 & JP-A-55 050 863 (Sumitomo Chem. Co., Ltd.) 14 Apr. 1980.
Patent Abstracts of Japan, vol. 16, No. 470 (C-0990) 30 Sep. 1992 & JP-A-04 169 528 (tanabe seiyaku co. ltd.) 17 Jun. 1992.
Heiko J. Luhmann and Uwe Heinemann, Journal of Neurophysiology, Apr. 1992, vol. 67, No. 4, pp. 798-811.
Green et al, Biochem J., (1971), vol. 123 pp. 781-791.

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