Biotherapeutic agents comprising recombinant PAP and PAP mutants

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

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4241421, 4241431, 4241471, 4241481, 4241831, 4241841, 4241871, A61K 39395, A61K 3940, A61K 3942, A61K 3944

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06146628&

ABSTRACT:
Biotherapeutic agents are provided which comprise recombinant PAP or a biologically equivalent variant or mutant thereof, linked to a targeting moiety which are effective for the treatment of certain human diseases. The invention further provides a process for producing the biotherapeutic agents as well as a method which utilizes the disclosed biotherapeutic agents to systemically treat cancer patients.

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