Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Patent
1995-06-07
1997-04-22
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
4352521, 4352523, 435852, 435877, 435878, C12P 1300
Patent
active
056228465
ABSTRACT:
Microorganisms of interest are capable of utilizing .alpha.-imino carboxamides, in the form of the racemate or of its optically active isomers, of the general formula ##STR1## wherein A together with --NH-- and --CH-- is an optionally substituted 5- or 6-membered saturated heterocyclic ring, as sole nitrogen source, and converting (RS)-.alpha.-imino carboximides of Formula I into an S-.alpha.-amino carboxylic acid of the general formula ##STR2## These microorganisms are useful also for biconversion of an (RS)-.alpha.-imino carboxamide of Formula I into an S-.alpha.-amino carboxylic acid.
REFERENCES:
M.C. Ng-Youn Chen et al., "Kinetic Resolution of Pipecolic Acid [. . . ]", J. Org. Chem., 1994, vol. 59, pp. 2075-2081.
J.W. Huh et al., "Total Conversion of Racemic Pipecolic Acid [. . . ]", Biosci. Biotech. Biochem., 1992, vol. 56, pp. 2081-2082.
J.W. Huh et al., "Synthesis of L-Proline [. . . ]", Journal of Fermentation and Bioengineering, 1992, vol. 74, pp. 189-190.
Kiener Andreas
Kohr J org
Roduit Jean-Paul
Shaw Nicholas
Lilling Herbert J.
Lonza AG
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