Biosynthetic uses of thermostable proteases

Details Biosynthetic uses of thermostable proteases Biosynthetic uses of thermostable proteases

1989-01-26

1992-05-26

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 88, C12P 1938, C12P 1940

Patent

active

051167417

ABSTRACT:
The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.

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