Biosynthetic gene ddl Streptococcus pneumoniae

Details Biosynthetic gene ddl Streptococcus pneumoniae Biosynthetic gene ddl Streptococcus pneumoniae

1997-04-15

1998-07-07

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 530350, G01N 3353, C07K 14315

Patent

active

057766959

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene ddl of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the DDL enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

REFERENCES:
Daub, et al., "Isolation, Cloning and Sequencing . . . ", Biochem. 27, 3701-3708 (1988).
Greenlee, et al., "Synthesis of an Analogue of Tabtoxinine as potential inhib. of alanine:alanine ligase" J. Med. Chem. 32, 165-170 (1989).
Zawadzke, et al., "Existence of Two D-alanine . . . " Biochem. 30, 1673-1682 (1991).
Fisher, et al., J. Bacteriol., 163 (1), 46-54.
Evers, et al., Gene, 140, 97-102.
Navarro, et al., Antimicrob. Agents and Chemotherapy, 38, (8), 1788-1793.
Al-BaR, et al., Biochem. J., 282, 747-752.

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