Biosynthetic gene DD1 from Streptococcus pneumoniae

Details Biosynthetic gene DD1 from Streptococcus pneumoniae Biosynthetic gene DD1 from Streptococcus pneumoniae

1996-07-25

1998-07-07

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435183, 4352523, 43525233, 4353201, 536 232, 536 237, C12N 121, C12N 1563, C12N 900, C07K 14315

Patent

active

057767335

ABSTRACT:
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene ddl of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the DDL enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

REFERENCES:
Fischer et al., J. Bacteriol., 163(1):46-54, 1985.
Evers et al., Gene, 140: 97-102, 1994.
Navarro et al., Antimicrob. Agents and Chemotherapy, 38, (8): 1788-1793, Aug. 1994.
Daub et al., Biochemistry, 27:3701-3708, 1988.
Al-BaR et al., Biochem. J., 282:747-752, 1992.
Daub et al. "Isolation, Cloning and Sequencing . . . " Biochem. 27, 3701-3708 (1988).
Greenlee et al. "Synthesis of an Analogue of Tabtoxinine as potential inhib. of alanine:alanine ligase" J. Med. Chem. 32, 165-170 (1989).
Zawadzke et al. "Existence of Two D-alanine . . . " Biochem. 30, 1673-1682 (1991).

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