Biosynthetic gene cluster for leptomycins

Details Biosynthetic gene cluster for leptomycins Biosynthetic gene cluster for leptomycins

2007-08-24

2010-12-14

Nashed, Nashaat T (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S196000, C435S252300, C435S252350, C435S320100, C536S023200, C536S023100

Reexamination Certificate

active

07851190

ABSTRACT:
Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic acids encoding leptomycin polyketide synthase domains or modifying enzymes.

REFERENCES:
patent: 7288396 (2007-10-01), Hu et al.
patent: 2005/0112726 (2005-05-01), Hu et al.

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