Biosynthetic anthracyclines related to daunorubicin

Details Biosynthetic anthracyclines related to daunorubicin Biosynthetic anthracyclines related to daunorubicin

1987-03-09

1990-07-17

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514183, 514270, 514908, 536 64, 540468, C07H 15252

Patent

active

049421557

ABSTRACT:
##STR1## are prepared by a biosynthetic process based on the addition of sodium salt of 1,3-N,N-dimethylbarbituric acid and 2-thiobarbituric acid respectively during the fermentation process of different micro-organisms such as Streptomyces peucetius and its mutants.
The novel compounds are provided with good antibacterial and antitumour activity.

REFERENCES:
Oki et al., Chem. Abst., vol. 95, 40852x (1981), eq. EP-26849.
Umezawa et al., Chem. Abst. 107-5725c (1987), eq. EP-206138.
Cassinelli et al., Chem. Abst., 100-50041t (1984).
Ganapathi et al., Chem. Abst., 102-249n (1985).
Krishan et al., Chem. Abst., 104-218544t (1986).
Cassinelli et al., CA 108-110869w (1988).
Komiyama et al., J. of Antibiotics, vol. 30, No. 7, p. 619 (1977).
Takahashi et al., J. of Antibiotics, vol. 30, No. 7, p. 622 (1977).

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