Biosynthesis of unnatural cephalosporins

Details Biosynthesis of unnatural cephalosporins Biosynthesis of unnatural cephalosporins

1985-02-06

1986-04-01

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 49, 435177, 435178, 435180, C12P 3500, C12P 3506, C12N 1102, C12N 1110

Patent

active

045798184

ABSTRACT:
A process is disclosed for converting a peptide precursor of the ACV type, in which the valine moiety may be replaced by any readily available amino acid, to an unnatural cephalosporin of the type ##STR1## where R.sub.1 is H, lower alkyl or functionalized carboxylic group and R.sub.2 is H or lower alkyl, in which the precursor is reacted with cyclase, epimerase and a ring expansion enzyme isolated from a cell-free extract of a prokaryotic organism such as Streptomyces clavuligerus. The three enzymes may be immobilized on a suitable support medium and the conversion may be carried out in a continuous mode.

REFERENCES:
patent: 4075061 (1978-02-01), Fleming et al.
patent: 4178210 (1979-12-01), Demain et al.
patent: 4248966 (1981-02-01), Demain et al.
patent: 4307192 (1981-12-01), Demain et al.
patent: 4510246 (1985-04-01), Wolfe et al.
Chibata, I., Immobilized Enzymes, Research and Development, John Wiley & Sons, N.Y., 1978, pp. 9-15 and 198-201.

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