Biosyntheses of salinosporamide A and its analogs and...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Reexamination Certificate

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C514S064000, C514S412000, C514S210060, C514S421000, C530S340000, C548S453000, C549S302000, C435S280000

Reexamination Certificate

active

07572606

ABSTRACT:
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.

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