Biostimulating agent

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form

Reexamination Certificate

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C424S464000, C424S489000

Reexamination Certificate

active

06287576

ABSTRACT:

BACKGROUND OF THE INVENTION
The present invention relates to drugs, more particularly to a biostimulating agent comprising natural minerals having ion-exchange and sorption properties, and biologically active vegetable stock. At present, it is well known to use as drugs natural minerals having sorption and ion-exchange properties. Natural zeolite with tuff-containing clinoptilolite 68-88 wt % used in particular as an antiallergic agent and as an agent for removing radionuclides accumulated in the body (see RF Patent No. 2063929, class A61K 33/00 and RF Patent No. 2082436, class A61K 33/00).
It is also well known to use a natural zeolite based biostimulating agent which further comprises an extract composed of verdant oak branches (RF Patent No. 2040269, A61K 35/78).
Well known in the art is also clay based drug which is characterized in that natural mineral illite constitutes at least 50% in said drug (French Patent No. 2717692, A61K 33/06). The drug is useful for external and internal administration in case of infectious diseases such as otitis, rheumatism, cystitis and also in case of gastric diseases. Besides, the drug is recommended as a general health improving.
It is well known to use natural mineral such as montmorillonite or clinoptilolite as enterosorbents for withdrawing toxic and pathogenic components from the body of warm-blooded animals and humans(RF Patent No. 2016576, A61K 33/00). To perform such administration, natural minerals are preliminary purified. The resulting mineral stock is introduced into the intestine. The optimum amount of a daily dose of the natural mineral ranges from 0.1 to 1.0 g per kg of the body weight.
The effect of all the drugs mentioned above is based on ion exchange and sorption properties of zeolite containing tuffs and montmorillonites. However, the known drugs do not permit using all possibilities of the abovementioned natural minerals which have a wide spectrum of macro-and microelements to a full degree.
SUMMARY AND OBJECTS OF THE INVENTION
The object of the invention is to provide biostimulating agents based on using both natural minerals having ion exchange and sorption properties and biologically active vegetable stock.
The biostimulating agent according to the invention is characterized in that that it comprises, as natural minerals, clinoptilolite-heulandite zeolite containing not less than 92 wt % clinoptilolite and/or not less than 92 wt % montmorillonite in montmorillonite clay, and biologically active vegetable stock, e.g., cereals such as oats or waste thereof, such as wheat and rye bran; sea algae such as Japanese laminaria (
Laminaria japonica Aresh
); higher plants such as madder (root) (
Rubia tinctorum
) higher fungi such as birch fungus (
Ionotus obliquus
).
The essence of the invention is to use to the fullest measure the properties of natural minerals as suppliers of macro-and microelements to the human organism, sorbents and ion exchangers capable of restoring normal mineral composition of the organism and thus promoting normalization of all metabolic processes. This is achieved by using a maximum of pure mineral stock containing not less than 92 wt % clinoptilolite and/or montmorillonite. Surprisingly it was found that a combination of zeolite and/or montmorilionite of such quality with biologically active vegetable stock makes it possible to maintain effectively the desired mineral salt balance in the body. When in the digestive tract, natural minerals are subjected to exchange reactions with digestion products. In this case, on the one hand, minerals become crushed, their active surface becomes large, and on the other hand, there occurs ion exchange in the “mineral-body” system. Micro-and macroelements present in the minerals diffuse into the body, whereas free mineral bonds are substituted by the elements which are present in the body in excessive amounts.
Use of various compositions based on the abovementioned minerals and biologically active vegetable stock intensifies specific properties of this vegetable stock. Useful compounds which are present in the vegetable stock become the most effective in the human body, provided there is a certain ratio of micro and macroelements essential both for entering these substances into the body from the intestine which process never takes place due to absence of micro- and macroelements and for allowing the entry of substances present in the vegetable stock into the metabolic processes in the body.
DESCRIPTION OF THE INVENTION
As disclosed in the invention, the biostimulating agents comprising up to 92 wt % of purified clinoptilolite and/or montmorillonite in combination with biologically active vegetable stock are, on an average, by 60-70% more effective than drugs containing individually mineral stock or individually biologically active vegetable stock. Such high effectiveness of the claimed agents results from a synergist effect of combination of mineral and vegetable stock that intensifies the activity of each other. In addition, the indirect effect of the mineral stock on the homeostasis regulation mechanism becomes stronger due to the fact that the body is capable of using most effectively the therapeutic potential of the biologically active vegetable stock. The biologically active vegetable stock accelerates, assisted by the active substances present therein, the processes of a positive effect of the mineral stock on the human body.
In order to prepare the biostimulating agent of the invention, natural minerals (e.g. Kholin deposit of zeolite-containing rocks) i.e. zeolites comprising clinoptilolite and heulandite and montmorillonite clay previously purified to not less than 92 wt % of clinoptilolite and its geochemical varieties or monotmorillonite are used.
In order to prepare the biostimulating agent of the present invention, biologically active, preferably dry vegetable stock, e.g. wheat and rye bran, oats, Japanese laminaria (Liminaria japonica Aresh) madder root (Rubia tinctorum), birch fungus (Ionotus obliquus) is used.
Bran is flour grinding production waste resulting from milling the grains. Bran comprises various particles of grain envelopes in admixture with flour and germs. Bran is the main supplier of cellulose which is a vitally important substrate without which the digestive tract and all the other systems in the human body cannot function properly. Cellulose, which is a main integral part of the vegetable cell envelope represents carbohydrate from the group of polysaccharides composed of glucose in molecule remnants. The main property of cellulose is its ability to adsorption. While in the intestine of the human body, cellulose starts imbibing a liquid thus binding simultaneously excessive amount of gastric juice enzymes and hydrochloric acid. Bran, while being a supplier of cellulose promotes optimization of enzymatic activity and reduces aggressiveness of the gastric juice. Bran, while acting indirectly through a pressure normalization mechanism in the bile duct and also normalizing peristatis of the duodenam and eliminatins congestion of a food clot, makes it possible to considerably alleviate the course of diseases such as cholecystitis and dyskinesia of the bileferous tracts.
From among cereals, oats is used. Oats is a cereal rich in protein, amino acids, vitamins, sugars, and fatty acids. Oats is one of the main sources of vegetable fats which are structural cell components.
In medical practice oats is used as a general health improving agent, and in case of intoxications as a diuretic cholagoque, sudorfic and enveloping agent. Oats is an agent which produces a pronounced positive effect in case of inflammatory diseases of the intestinal tract (chronic cholecystitis, gastritis duodenitis, enteritis or the like). Besides, polyphenols present in oats promote reducing cholesterol and low-density lipoproteides causing development of atherosclerosis.
Japanese Laminaira (
Laminaria japonica Aresh
) is a valuable supplier of organic iodine compounds which improve assimilation of protein, phosphorus, calcium and iron, reduce the viscosity of blood,

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