Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1995-12-01
1999-01-26
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
523113, 424423, 424426, 424484, C08L 8900, A61F 200
Patent
active
058639845
ABSTRACT:
Biomaterials like collagen can be designed for use as scaffolds for connective tissue reconstruction. It is known that proteins conjugated with PEGs exhibit a decrease in their biodegradation rate and their immunogenicity. Different concentrations and molecular weights of PEGs (PEG-750 and PEG-5000) were conjugated by chemical or irradiation means to collagen materials (films or sponges) which were then investigated by physicochemical assays, collagenase assay, fibroblast cell culture and subcutaneous implantation. PEG-conjugation delayed the degradation by collagenase and preserved a normal fibroblasts morphology and confluency in culture. In vivo, the porous structure of non-modified sponges was collapsed by day 15 with few observable fibroblasts between the collagen fibers. In PEG-modified collagen sponges, the porous structure remained stable for at least 30 days. Cell infiltration was particularly enhanced in PEG-750-conjugated collagen sponges. In conclusion, PEGs conjugated onto collagen sponges stabilize the porous structure without deactivating the biological properties of collagen. These porous composite materials could advantageously function as a scaffold to organize tissue ingrowth. Therefore, the present invention relates to a porous biomaterial whose porosity is stabilized by conjugation to PEG-derivatives. Biopolymers other than collagen may be used in the making of such composite materials.
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C. -Gaudreault René
Doillon charles J.
Pietrucha Krystina
Nutter Nathan M.
Universite Laval, Cite Universitaire
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