Biospecific binding reactants labelled with luminescent lanthani

Details Biospecific binding reactants labelled with luminescent lanthani Biospecific binding reactants labelled with luminescent lanthani

1995-10-25

1999-01-12

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

424 936, 424 934, 424 96, 436172, 546 2, 546 5, 546 6, 546256, C07F 500, A61K 4900, G01N 2176, C07D21300

Patent

active

058592156

ABSTRACT:
This invention relates to a detectable molecule comprising a biospecific binding reactant attached to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of the formula ##STR1## wherein --A-- is a bivalent aromatic structure selected from the group consisting of ##STR2## One of the two groups G.sub.1 or G.sub.2 is used for coupling the chelate to a biospecific binding reactant. The lanthanide ion is europium(III), terbium(III), dysprosium (III) or samarium (III).

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Modesto J. Remuinan et al., "Synthesis and Luminiscence Properties of Europium (III) and Terbium (III) Complexes with Polyacid Chelates Derived from 2,6-Bis (N-pyrazolyl)pyridine", J. Chem. Soc. Perkin Trans., 2, 1993, pp. 1099-1102.

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