Biosensors with porous dielectric surface for fluorescence...

Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation

Reexamination Certificate

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C356S311000

Reexamination Certificate

active

07869032

ABSTRACT:
Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO2. In one example the porous, thin film is in the form of a multitude of sub-micron sized rod-like structures (“nanorods”) projecting therefrom. In one embodiment, the biosensor is in the form of a photonic crystal biosensor. The approach of depositing a thin film of dielectric nanorods may be applied to any enhanced fluorescence biosensor surface structure, including 1-dimensional photonic crystals, 2-dimensional photonic crystals, 3-dimensional photonic crystals, surface plasmon resonance surfaces, planar waveguides, and grating-coupled waveguides. The dielectric nanorod structures can be fabricated on the surface of a biosensor by the glancing angle deposition technique (GLAD).

REFERENCES:
patent: 5216680 (1993-06-01), Magnusson et al.
patent: 6990259 (2006-01-01), Cunningham
patent: 7094595 (2006-08-01), Cunningham et al.
patent: 7118710 (2006-10-01), Cunningham
patent: 7167615 (2007-01-01), Wawro et al.
patent: 7400399 (2008-07-01), Wawro et al.
patent: 2002/0127565 (2002-09-01), Cunningham et al.
patent: 2003/0026891 (2003-02-01), Qui et al.
patent: 2003/0027327 (2003-02-01), Cunningham et al.
patent: 2003/0059855 (2003-03-01), Cunningham et al.
patent: 2006/0252065 (2006-11-01), Zhao et al.
patent: 2006/0281077 (2006-12-01), Lin et al.
patent: 2007/0009380 (2007-01-01), Cunningham
patent: 2007/0009968 (2007-01-01), Cunningham et al.
patent: 2007/0015151 (2007-01-01), Schrenzel et al.
Y. J. Hung, I. I. Smolyaninov, C. C. Davis, and H. C. Wu, “Fluorescence enhancement by surface gratings,”Optics Express, vol. 14, pp. 10825-10830, 2006.
T. Hayakawa, S. T. Selvan, and M. Nogami, “Field enhancement effect of small Ag particles on the fluorescence from Eu3+-doped SiO2 glass,”Applied Physics Letters, vol. 74, pp. 1513-1515, 1999.
K. Asian, S. N. Malyn, and C. D. Geddes, “Metal-enhanced fluorescence from gold surfaces: Angular dependent emission,”Journal of Fluorescence, vol. 17, pp. 7-13, 2007.
K. Aslan, I. Gryczynski, J. Malicka, E. Matveeva, J. R. Lakowicz, and C. D. Geddes, “Metal-enhanced fluorescence: an emerging tool in biotechnology,”Current Opinion in Biotechnology, vol. 16, pp. 55-62, 2005.
W. Budach, D. Neuschafer, C. Wanke, and S. D. Chibout, “Generation of transducers for fluorescence-based microarrays with enhanced sensitivity and their application for gene expression profiling,”Analytical Chemistry, vol. 75, No. 11, pp. 2571-2577, 2003.
P. C. Mathias, N. Ganesh, L. L. Chan, and B. T. Cunningham, “Combined enhanced fluorescence and label-free biomolecular detection with a photonic crystal surface,”Applied Optics, vol. 46, No. 12, pp. 2351-2360, 2007.
N. Ganesh, W. Zhang, P. C. Mathias, E. Chow, J. A. N. T. Soares, V. Malyarchuk, A. D. Smith, and B. T. Cunningham, “Enhanced fluorescence emission from quantum dots on a photonic crystal surface,”Nature Nanotechnology, vol. 2, pp. 515-520, 2007.
N. Ganesh and B. T. Cunningham, “Photonic-crystal near-ultraviolet reflectance filters fabricated by nanoreplica molding,”Applied Physics Letters, vol. 88, pp. 071110-1-071110-3 2006.
C. J. Choi and B. T. Cunningham, “Single-step fabrication and characterization of photonic crystal biosensors with polymer microfluidic channels,”Lab on a Chip, vol. 6, pp. 1373-1380, 2006.
B. T. Cunningham, P. Li, S. Schulz, B. Lin, C. Baird, J. Gerstenmaier, C. Genick, F. Wang, E. Fine, and L. Laing, “Label-free assays on the BIND system,”Journal of Biomolecular Screening, vol. 9, pp. 481-490, 2004.
S. S. Wang, R. Magnusson, J. S. Bagby, and M. G. Moharam, “Guided-Mode Resonances in Planar Dielectric-Layer Diffraction Gratings,”Journal of the Optical Society of America-Optics Image Science and Vision, vol. 7, No. 8, pp. 1470-1474, 1990.
R. Magnusson and S. S. Wang, “New Principle for Optical Filters,”Applied Physics Letters, vol. 61, No. 9, pp. 1022-1024, 1992.
S. S. Wang and R. Magnusson, “Theory and Applications of Guided-Mode Resonance Filters,”Applied Optics, vol. 32, No. 14, pp. 2606-2613, 1993.
C. Y. Wei, S. J. Liu, D. G. Deng, J. Shen, J. D. Shao, and Z. X. Fan, “Electric field enhancement in guided-mode resonance filters,”Optics Letters, vol. 31, No. 9, pp. 1223-1225, 2006.
Cunningham, B.T., P. Li, B. Lin and J. Pepper, “Colorimetric Resonant Reflection as a Direct Biochemical Assay Technique,”Sensor and Actuators B, vol. 81, pp. 316-328, 2002.
Cunningham, B.T.J. Qiu, P. Li, J. Pepper and B. Hugh, “A Plastic Calorimetric Resonant Optical Biosensor for Multiparallel Detection of Label Free Biochemical Interactions,”Sensors and Actuators B, vol. 85, pp. 219-226, 2002.
J. G. W. v. d. Waterbeemd and G. W. v. Oosterhout, “Effect of the Mobility of Metal Atoms on the Structure of Thin Films Deposited at Oblique Incidence,”Philips Res. Rep., vol. 22, pp. 375-387, 1967.
K. Robbie, L. J. Friedrich, S. K. Dew, T. Smy, and M. J. Brett, “Fabrication of Thin-Films with Highly Porous Microstructures,”Journal of Vacuum Science&Technology A-Vacuum Surfaces and Films, vol. 13, pp. 1032-1035, 1995.
L. Abelmann and C. Lodder, “Oblique evaporation and surface diffusion,”Thin Solid Films, vol. 305, pp. 1-21, 1997.
Lin et al.,A Porous Silicon-Based Optical Interferometric Biosensor, Science vol. 278, pp. 840-844 (1997).
Wang et al., “Glucose oxidase entrapped in polypyrrole on high-surface-area Pt electrodes: a model platform for sensitive electroenzymatic biosensors,”Journal of Electroanalytical Chemistry, vol. 575, pp. 139-146, 2005.
Zhao et al., “Designing Nanostructures by Glancing Angle Deposition”, Proceedings of SPIE (online), vol. 5219, Nanotubes and Nanowires, pp. 59-73 (SPIE, Bellingham, WA).
International Search Report and Written Opinion in PCT/US28/03854, dated Jul. 1, 2008.
Wawro et al.,Optical Fiber Endface Biosensor Based on Resonances in Dielectric Waveguide Gratings, International Biomedical Optics Symposium Jan. 2000, Proceedings SPIE, vol. 3911, pp. 86-94 (2000).
International Preliminary Examination Report dated Oct. 15, 2009 in PCT/US2008/003854, filed Mar. 24, 2008.

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