Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-09-18
2007-09-18
Le, Long V. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C422S082050, C422S082060, C422S082070, C422S082080, C435S007100, C435S287200, C436S172000, C530S387100, C530S391100
Reexamination Certificate
active
10204431
ABSTRACT:
The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
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Bedouelle Hugues
Belkadi Laurent
England Patrick
Renard Martial
Centre National de la Recherche Scientifique--CNRS
Institut Pasteur
Jung Unsu
Le Long V.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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