Biosensors including lipid bilayer doped with ion channels ancho

Details Biosensors including lipid bilayer doped with ion channels ancho Biosensors including lipid bilayer doped with ion channels ancho

1991-01-09

1993-04-20

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435817, 435288, 435291, 436525, 436527, 436501, C12Q 100, G01N 3353, G01N 33566, C12M 140

Patent

active

052042391

ABSTRACT:
Biosensors for qualitative and quantitative analysis comprise an amphipathic liquid crystalline membrane composed of a lipid bilayer attached to a recording electrode via bridging anchoring molecules. The lipid bilayer is doped with biologic or synthetic ion channels and is in continuous contact with a bulk aqueous medium on both its surfaces. The bridging anchoring molecules may contain a phospholipid moiety linked to a polyoxylakylene chain terminated with a thiol or thioether residue.

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Sprag et al (1986) PUA883:5494-5497.
Rybak et al (1988) Blood 72:714-20 (Abstract Only).
Umezawa et al., (1989) "Chemical Sensor Mechanisms . . . " Ion-Selective Electrodes, 5, ed. E. Pungor, Pergamon Press.

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