Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2011-05-10
2011-05-10
Crow, Robert T (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S006120, C435S007100, C536S023100, C536S024300
Reexamination Certificate
active
07939313
ABSTRACT:
The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.
REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5543293 (1996-08-01), Gold et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5582981 (1996-12-01), Toole et al.
patent: 5637459 (1997-06-01), Burke et al.
patent: 5641629 (1997-06-01), Pitner et al.
patent: 5650275 (1997-07-01), Pitner et al.
patent: 5660985 (1997-08-01), Pieken et al.
patent: 5670637 (1997-09-01), Gold et al.
patent: 5683867 (1997-11-01), Biesecker et al.
patent: 5688935 (1997-11-01), Stephens et al.
patent: 5696249 (1997-12-01), Gold et al.
patent: 5705337 (1998-01-01), Gold et al.
patent: 5712375 (1998-01-01), Jensen et al.
patent: 5723289 (1998-03-01), Eaton et al.
patent: 5723592 (1998-03-01), Eaton et al.
patent: 5750342 (1998-05-01), Stephens et al.
patent: 5756291 (1998-05-01), Griffin et al.
patent: 5763566 (1998-06-01), Jensen et al.
patent: 5763595 (1998-06-01), Gold et al.
patent: 5773598 (1998-06-01), Burke et al.
patent: 5789157 (1998-08-01), Jensen et al.
patent: 5789160 (1998-08-01), Eaton et al.
patent: 5817785 (1998-10-01), Gold et al.
patent: 5840867 (1998-11-01), Toole et al.
patent: 5843653 (1998-12-01), Gold et al.
patent: 5853984 (1998-12-01), Davis et al.
patent: 5858660 (1999-01-01), Eaton et al.
patent: 5861254 (1999-01-01), Schneider et al.
patent: 5864026 (1999-01-01), Jensen et al.
patent: 5874218 (1999-02-01), Drolet et al.
patent: 5958691 (1999-09-01), Pieken et al.
patent: 5962219 (1999-10-01), Gold et al.
patent: 5989823 (1999-11-01), Jayasena et al.
patent: 5998142 (1999-12-01), Gold et al.
patent: 6001570 (1999-12-01), Grossman
patent: 6001577 (1999-12-01), Gold et al.
patent: 6011020 (2000-01-01), Gold et al.
patent: 6013443 (2000-01-01), Heilig et al.
patent: 6030776 (2000-02-01), Eaton et al.
patent: 6048698 (2000-04-01), Eaton et al.
patent: 6083696 (2000-07-01), Biesecker et al.
patent: 6110900 (2000-08-01), Gold et al.
patent: 6114120 (2000-09-01), Jensen et al.
patent: 6127119 (2000-10-01), Stephens et al.
patent: 6147204 (2000-11-01), Gold et al.
patent: 6177555 (2001-01-01), Jayasena et al.
patent: 6207388 (2001-03-01), Grossman
patent: 6225058 (2001-05-01), Munishkin et al.
patent: 6261774 (2001-07-01), Pagratis et al.
patent: 6261783 (2001-07-01), Jayasena et al.
patent: 6287772 (2001-09-01), Stefano
patent: 6291184 (2001-09-01), Gold et al.
patent: 6300074 (2001-10-01), Gold et al.
patent: 6329145 (2001-12-01), Janjic et al.
patent: 6331398 (2001-12-01), Gold et al.
patent: 6344318 (2002-02-01), Gold et al.
patent: 6376190 (2002-04-01), Gold et al.
patent: 6391593 (2002-05-01), Weston et al.
patent: 6399302 (2002-06-01), Lannigan et al.
patent: 6423493 (2002-07-01), Gorenstein et al.
patent: 6451588 (2002-09-01), Egholm et al.
patent: 6465188 (2002-10-01), Gold et al.
patent: 6506887 (2003-01-01), Smith et al.
patent: 6544746 (2003-04-01), Heyduk
patent: 6593091 (2003-07-01), Keys
patent: 6613526 (2003-09-01), Heilig et al.
patent: 6680377 (2004-01-01), Stanton et al.
patent: 6716583 (2004-04-01), Gold et al.
patent: 6730482 (2004-05-01), Gold et al.
patent: 6815164 (2004-11-01), Kurn
patent: 6878515 (2005-04-01), Landegren
patent: 6916613 (2005-07-01), Munishkin et al.
patent: 7306904 (2007-12-01), Landegren
patent: 2002/0022224 (2002-02-01), Hornby et al.
patent: 2002/0037506 (2002-03-01), Lin et al.
patent: 2002/0051986 (2002-05-01), Baez et al.
patent: 2002/0064779 (2002-05-01), Landegren
patent: 2003/0087239 (2003-05-01), Stanton et al.
patent: 2003/0207271 (2003-11-01), Holwitt et al.
patent: 2003/0224435 (2003-12-01), Seiwert
patent: 2003/0232383 (2003-12-01), Daunert
patent: 2003/0232388 (2003-12-01), Kreimer et al.
patent: 2004/0053310 (2004-03-01), Shi et al.
patent: 2004/0058378 (2004-03-01), Kong et al.
patent: 2004/0067501 (2004-04-01), Kage
patent: 2004/0180360 (2004-09-01), Wilson et al.
patent: 2004/0219523 (2004-11-01), Stanton et al.
patent: 2005/0069910 (2005-03-01), Turner et al.
patent: 2005/0095627 (2005-05-01), Kolman
patent: 2005/0106594 (2005-05-01), Ellington et al.
patent: 2005/0112710 (2005-05-01), Torres et al.
patent: 2006/0110739 (2006-05-01), Heyduk
patent: 2008/0044834 (2008-02-01), Heyduk
patent: 2008/0171322 (2008-07-01), Heyduk
patent: 9700446 (1997-01-01), None
patent: 0070329 (2000-11-01), None
patent: 03064657 (2003-08-01), None
patent: WO 03/064657 (2003-08-01), None
patent: WO 03/078449 (2003-09-01), None
patent: 2005059509 (2005-06-01), None
patent: 2006128138 (2006-11-01), None
SantaLucia, A unified view of polymer, dumbell and oligonucleotide DNA nearest-neighbor thermodynamics, 1998, PNAS, 95, 1460-1465.
Zalipsky, Chemistry of polyethylene glycol conjugate with biologically active molecules, 1995, Advanced drug Delivery Reviews, 1995, 16, 157-182.
Wikipedia Brochure.
Uptima Brochure.
Bock, L.C., et al., “Selection of single-stranged DNA molecules that bind and inhibit human thrombin”,Nature(1992) pp. 564-566, vol. 355.
Burgstaller, P., et al. , “Synthetic Ribozymes and the First Deoxyribozyme”,Angew. Chem. Int. Ed. Engl.(1995) pp. 1189-1192, vol. 34, No. 11.
Ellington, A.D., et al., “In vitro selection of RNA molecules that bind specific ligands”,Nat.(1990) pp. 818-822, vol. 346.
Famulok, M., et al., “In Vitro Selection of Specific Ligand-binding Nucleic Acids”,Angew. Chem. Int. Ed. Engl.(1992) pp. 979-988, vol. 31.
Fang, et al., “Synthetic DNA Aptamers to Detect Protein Molecular Variants in a High-Throughput Fluorescence Quencing Assay”,ChemBioChem. (2003) pp. 829-834, vol. 4.
Gold, L., et al., “Diversity of Oligonucleotide Functions”,Ann. Rev. Biochem. (1995) pp. 763-797, vol. 64.
Hamaguchi, et al., “Aptamer Beacons for the Direct Detection of Proteins”,Analy. Biochem. (2001) pp. 126-131, vol. 294.
Heyduk, E., et al., “Thiol-reactive, Luminescent Europium Chelates: Luminescence Probes for Resonance Energy Transfer Distance Measurements in Biomolecules”,Anal. Biochem. (1997) pp. 216-227, vol. 248.
Heyduk, E., et al., “Conformational Changes of DNA Induced by Binding ofChironomusHigh Mobility Group Protein 1a (cHMG1a)”,J. Biol. Chem. (1997) pp. 19763-19770, vol. 272, No. 32.
Heyduk, E., et al., “Homogeneous Fluorescence Assay for Cyclic AMP”,Comb. Chem. and High Throughput Screen. (2003) pp. 347-354, vol. 6.
Heyduk, T., et al., “Luminescense Energy Transfer with Lanthanide Chelates: Interprepation of Sensitized Acceptor Decay Amplitudes”,Analy Biochem(2001) pp. 60-67, vol. 289, No. 1.
Heyduk, T., et al., “Molecular beacons for detecting DNA binding proteins”,Nat. Biotech. (2002) pp. 171-176, vol. 20.
Heyduk, E., et al., “Molecular beacons for detecting DNA binding proteins: mechanism of action”,Analyt. Biochem. (2003) pp. 1-10, vol. 316.
Jayasena, S.D., “Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics”,Clin. J. Chem. (1999) pp. 1628-1650, vol. 45, No. 9.
Klug, S., et al., “All you wanted to know about SELEX (but were afraid to ask . . . )”,Mol. Biol. Rep(1994) pp. 97-107, vol. 20.
Knoll, E., et al., “Unimolecular Beacons for the Detection of DNA-Binding Proteins”,Anal. Chem. (2004) pp. 1156-1164, vol. 76, No. 4.
Li, J.J., et al., “Molecular Aptamer Beacons for Real-Time Protein Recognition”,Biochem. and Biophys. Res. Commun. (2002) pp. 31-40, vol. 292, No. 1.
Mathis, G., “Probing Molecular Interactions with Homogeneous Techniques Based on Rare Earth Cryptrates and Fluorescence Energy Transfer”,Clinic. Chem. (1995) pp. 1391-1397, vol. 41, No. 9.
Matlock, D.L., et al., “Sequence Determinants for the Recognition of the Fork Junction DNA Containing the -10 Region of Promote
Heyduk Ewa
Heyduk Tomasz
Knoll Eric
Bhat Narayan K
Crow Robert T
Polsinelli Shughart PC
Saint Louis University
LandOfFree
Biosensors for detecting macromolecules and other analytes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biosensors for detecting macromolecules and other analytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biosensors for detecting macromolecules and other analytes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2667154