Biosensors

Details Biosensors Biosensors

1986-04-04

1989-08-15

Hill, Jr., Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

350 9612, 350 9615, 350 9619, 350 9634, 422 55, 422 57, 422 69, 435287, 435291, 435808, 436805, G01N 2177

Patent

active

048572730

ABSTRACT:
A biosensor includes an optically dense body provided with a coating sensitized to a specific assay species, and an input and output coupling structure. Light signal response is enhanced by incorporating a partially reflecting, partially transmitting medium between the coupling structure and the optically dense body having a lower refractive index. The thickness of such medium is chosen so that light may be coupled by frustrated total internal reflection and to enable the medium to serve as a resonant mirror.

REFERENCES:
patent: 3883221 (1975-05-01), Rigrod
patent: 4059338 (1977-11-01), Hartelius
patent: 4565422 (1986-01-01), Seymour et al.
patent: 4582809 (1986-04-01), Block et al.
patent: 4637684 (1987-01-01), Tomita et al.
patent: 4653844 (1987-03-01), Ward
CRC Handbook of Chemistry and Physics, 64th Edition, CRC Press, Boca Raton, Fla., 1983-1984, p. B-66.
R. M. Sutherland et al., "Detection of Antibody-Antigen Reactions at a glass liquid interface as a Novel Optical Immunoassay Concept". Proceedings of 2nd Optical Fiber Conference (Stuttgart 1984), Paper, No. 28, p. 75.

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