Electrolysis: processes – compositions used therein – and methods – Electrolytic analysis or testing – Involving enzyme or micro-organism
Reexamination Certificate
2011-08-16
2011-08-16
Olsen, Kaj K (Department: 1724)
Electrolysis: processes, compositions used therein, and methods
Electrolytic analysis or testing
Involving enzyme or micro-organism
C205S792000, C204S403040, C204S403120
Reexamination Certificate
active
07998337
ABSTRACT:
The present invention is based on the discovery of NAD+and NADP+mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
REFERENCES:
patent: 4490464 (1984-12-01), Gorton et al.
patent: 4654127 (1987-03-01), Baker et al.
patent: 4758323 (1988-07-01), Davis et al.
patent: 4946562 (1990-08-01), Guruswamy
patent: 5096669 (1992-03-01), Lauks et al.
patent: 5120420 (1992-06-01), Nankai et al.
patent: 5126034 (1992-06-01), Carter et al.
patent: 5212622 (1993-05-01), MacFarlane et al.
patent: 5266179 (1993-11-01), Nankai et al.
patent: 5512159 (1996-04-01), Yoshioka et al.
patent: 5582697 (1996-12-01), Ikeda et al.
patent: 5628890 (1997-05-01), Carter et al.
patent: 5651869 (1997-07-01), Yoshioka et al.
patent: 5705045 (1998-01-01), Park et al.
patent: 2002/0092612 (2002-07-01), Davies et al.
patent: 2004/0031682 (2004-02-01), Wilsey
patent: 0 125 867 (1984-11-01), None
patent: 0 732 406 (1996-09-01), None
patent: 0 794 429 (1997-09-01), None
patent: 2 188 728 (1987-10-01), None
patent: 7248310 (1995-09-01), None
patent: 07 209 243 (1995-11-01), None
patent: 8094573 (1996-04-01), None
patent: 8334489 (1996-12-01), None
patent: 9145665 (1997-06-01), None
Wu et al, Analytical Chemistry 1996, 68, pp. 3688-3696.
Bard and Faulkner, Electrochemical Methods, Fundamentals and Applications, John Wiley & Sons, 1980, pp. 22-26.
Carlson, et al., “Mechanism of the Oxidation of NADH by Quinones. Energetic of One-Electron and Hydride Routes”, Journal of American Chemical Society, vol. 107, pp. 479-485 (1985).
Eckert, et al., “Some electrochemical and chemical properties of methoxatin and analogous quinoquinones”, Proc. Natl. Acad. Sci. USA, vol. 79; pp. 2533-2536 (1982).
Eckert, et al., “Chemical Properties of Phenanthrolinequinones and the Mechanism of Amine Oxidation by o-Wuinones of Medium Redox Potentials”, Journal of American Chemical Society, vol. 105, pp. 4431-4441 (1983).
Geng, et al. “Amperometric biosensors based on dehydrogenase/NAD and heterocyclic quinones”, Biosensors and Bioelectronics, vol. 11, No. 12, pp. 1267-1275 (1996).
Gillard, et al., “Optically Active Co-ordination Compounds. Part XX. Reactions of 1, 10-Phenanthroline co-ordinated to Cobalt (III)”, Journal of the Chemical Society, A., pp. 1447-1451 (1970).
Goss, et al., “Spectral, Electrochemical, and Electrocatalytic Properties of 1, 10-Phenanthroline-5,6-dione Complexes of Transition Metals”, Inorganic Chemistry, vol. 24, pp. 4263-4267 (1985).
Mullins, et al., “Preparation of some new intercalating europium(III) sensitizers”, J. Chem. Soc., Perkin Trans. vol. 1, pp. 75-81 (1996).
Surrey, “Pyocyanine”, Organic Synthesis, vol. 3, Ed. E.C. Horning, Wiley, New York, pp. 753-756.
Yosioka, Yakugaku Zasshi, “Studies of Phenazines. III. Wohl-Aue Reactions of m-Nitroanisole and m-Anisidine”, vol. 73, pp. 23-25 (1953).
Batchelor, et al., “Amperometric Assay for the Ketone Body 3-Hydroxybutrate”, Anal. Chim. Acta., 221, 1989, pp. 289-294.
Itoh et al., Chemistry Letters, vol. 8, pp. 1583-1586, 1992.
Hedenmo et al, Analyst, 1996, vol. 121, pp. 1891-1895.
Hilt et al, Chemistry A European Journal, vol. 3, pp. 79-88, 1997.
Wikipedia entry for beta-hydroxybutyrate, date unknown. (892 FORM, May 27, 2010, Re: U.S. Appl. No. 11/849,790).
Forrow Nigel J.
Sanghera Gurdial S.
Walters Stephan
Watkin Jared L.
Abbott Laboratories
Baba Edward J.
Bozicevic Field & Francis LLP
Chin Khin K.
Olsen Kaj K
LandOfFree
Biosensor electrode mediators for regeneration of cofactors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biosensor electrode mediators for regeneration of cofactors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biosensor electrode mediators for regeneration of cofactors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2677697